Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy

Elisa Baldin, S. Testoni, S. de Pasqua, Salvatore Ferro, Fiorenzo Albani, Agostino Baruzzi, Roberto Dalessandro, A. Baruzzi, F. Albani, F. Calbucci, R. D’Alessandro, Roberto Michelucci, A. Brandes, V. Eusebi, S. Ceruti, Enrico Fainardi, R. Tamarozzi, Ermanno Emiliani, Michele Cavallo, Enrico FranceschiAlicia Tosoni, M. Cavallo, F. Fiorica, A. Valentini, R. Depenni, C. Mucciarini, Girolamo Crisi, E. Sasso, Claudia Biasini, Luigi Cavanna, D. Guidetti, N. Marcello, Anna Pisanello, Anna Cremonini, G. Guiducci, S. de Pasqua, S. Testoni, Raffaele Agati, G. Ambrosetto, Antonella Bacci, Elisa Baldin, A. Baldrati, Eveline Barbieri, Stefania Bartolini, Elena Bellavista, Francesca Bisulli, Elena Bonora, F. Bunkheila, V. Carelli, Mauro Crisci, P. Dall’Occa, Salvatore Ferro, Claudio Franceschi, Giampiero Frezza, V. Grasso, Marco Leonardi, Barbara Mostacci, G. Palandri, Elena Pasini, M. Pastore Trossello, R. Poggi, Patrizia Riguzzi, R. Rinaldi, S. Rizzi, G. Romeo, F. Spagnolli, P. Tinuper, C. Trocino, Monia Dall'Agata, M. Faedi, Massimo Frattarelli, G. Gentili, A. Giovannini, P. Iorio, U. Pasquini, G. Galletti, Carlo Guidi, Walter Neri, A. Patuelli, S. Strumia, M. Casmiro, A. Gamboni, Fabrizio Rasi, G. Cruciani, P. Cenni, C. Dazzi, A. R. Guidi, Federica Zumaglini, Andrea Amadori, G. Pasini, M. Pasquinelli, Ernesto Pasquini, Antonio Polselli, Alessandro Ravasio, B. Viti, M. Sintini, A. Ariatti, Francesco Bertolini, G. Bigliardi, Paolo Carpeggiani, F. Cavalleri, S. Meletti, Paolo Nichelli, E. Pettorelli, GianPietro Pinna, E. Zunarelli, F. Artioli, I. Bernardini, M. Costa, G. Greco, R. Guerzoni, C. Stucchi, C. Iaccarino, Moira Ragazzi, R. Rizzi, Giulio Zuccoli, P. Api, F. Cartei, E. Fallica, Enrico Granieri, F. Latini, G. Lelli, Cinzia Monetti, Andrea Saletti, R. Schivalocchi, Silvia Seraceni, Maria Rosalia Tola, Benedetta Urbini, Carlotta Giorgi, E. Montanari, Davide Cerasti, Pellegrino Crafa, I. Dascola, I. Florindo, E. Giombelli, S. Mazza, V. Ramponi, F. Servadei, E. M. Silini, P. Torelli, Paolo Immovilli, N. Morelli, C. Vanzo, C. Nobile

Research output: Contribution to journalArticle

Abstract

Incidence of neuroepithelial Primary Brain Tumors (nPBT) varies, ranging from 7.3 to 11.6 cases/100,000/year across Europe. We present incidence and survival of nPBT in the Emilia-Romagna region (ER), Italy. This study is the largest in Southern Europe. Specialists in neurosurgery, neurology, neuroradiology, oncology, radiotherapy, genetics, and pathology of ER notified all suspected nPBT adult cases residing in ER (4,337,966 inhabitants) observed during 2009. Furthermore, through ICD-9 discharge codes, we identified and reviewed all possible cases. Neuroepithelial PBT diagnosis was based on histological or radiological findings. We included 400 incident nPBT cases, of which 102 (25%) were retrospectively identified. These latter were significantly older. The standardized incidence was 10.5/100,000/year (95% CI 9.4–11.5), higher for men. It was 9.2/100,000/year (95% CI 8.3–10.2) for astrocytic tumors, 0.6/100,000/year (95% CI 0.4–0.9) for oligodendroglial tumors, and 7.1 (95% CI 6.3–8.0) for glioblastoma (GBM). Among GBM patients, median survival was 249 days if prospectively identified vs. 132 days when identified through ICD-9 codes (p < 0.0001). The incidence of nPBT in the ER region is among the highest in the literature. Older patients were more likely to escape an active surveillance system. This should be considered when comparing incidence rates across studies, giving the increasing number of elderly people in the general population.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalNeurological Sciences
DOIs
Publication statusAccepted/In press - Nov 2 2016

Fingerprint

Brain Neoplasms
Italy
International Classification of Diseases
Incidence
Population
Glioblastoma
Survival
Neurosurgery
Neurology
Neoplasms
Radiotherapy
Pathology

Keywords

  • Epidemiology
  • Glioblastoma
  • Incidence rate
  • Primary brain tumors
  • Survival

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Baldin, E., Testoni, S., de Pasqua, S., Ferro, S., Albani, F., Baruzzi, A., ... Nobile, C. (Accepted/In press). Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy. Neurological Sciences, 1-8. https://doi.org/10.1007/s10072-016-2747-y

Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy. / Baldin, Elisa; Testoni, S.; de Pasqua, S.; Ferro, Salvatore; Albani, Fiorenzo; Baruzzi, Agostino; Dalessandro, Roberto; Baruzzi, A.; Albani, F.; Calbucci, F.; D’Alessandro, R.; Michelucci, Roberto; Brandes, A.; Eusebi, V.; Ceruti, S.; Fainardi, Enrico; Tamarozzi, R.; Emiliani, Ermanno; Cavallo, Michele; Franceschi, Enrico; Tosoni, Alicia; Cavallo, M.; Fiorica, F.; Valentini, A.; Depenni, R.; Mucciarini, C.; Crisi, Girolamo; Sasso, E.; Biasini, Claudia; Cavanna, Luigi; Guidetti, D.; Marcello, N.; Pisanello, Anna; Cremonini, Anna; Guiducci, G.; de Pasqua, S.; Testoni, S.; Agati, Raffaele; Ambrosetto, G.; Bacci, Antonella; Baldin, Elisa; Baldrati, A.; Barbieri, Eveline; Bartolini, Stefania; Bellavista, Elena; Bisulli, Francesca; Bonora, Elena; Bunkheila, F.; Carelli, V.; Crisci, Mauro; Dall’Occa, P.; Ferro, Salvatore; Franceschi, Claudio; Frezza, Giampiero; Grasso, V.; Leonardi, Marco; Mostacci, Barbara; Palandri, G.; Pasini, Elena; Pastore Trossello, M.; Poggi, R.; Riguzzi, Patrizia; Rinaldi, R.; Rizzi, S.; Romeo, G.; Spagnolli, F.; Tinuper, P.; Trocino, C.; Dall'Agata, Monia; Faedi, M.; Frattarelli, Massimo; Gentili, G.; Giovannini, A.; Iorio, P.; Pasquini, U.; Galletti, G.; Guidi, Carlo; Neri, Walter; Patuelli, A.; Strumia, S.; Casmiro, M.; Gamboni, A.; Rasi, Fabrizio; Cruciani, G.; Cenni, P.; Dazzi, C.; Guidi, A. R.; Zumaglini, Federica; Amadori, Andrea; Pasini, G.; Pasquinelli, M.; Pasquini, Ernesto; Polselli, Antonio; Ravasio, Alessandro; Viti, B.; Sintini, M.; Ariatti, A.; Bertolini, Francesco; Bigliardi, G.; Carpeggiani, Paolo; Cavalleri, F.; Meletti, S.; Nichelli, Paolo; Pettorelli, E.; Pinna, GianPietro; Zunarelli, E.; Artioli, F.; Bernardini, I.; Costa, M.; Greco, G.; Guerzoni, R.; Stucchi, C.; Iaccarino, C.; Ragazzi, Moira; Rizzi, R.; Zuccoli, Giulio; Api, P.; Cartei, F.; Fallica, E.; Granieri, Enrico; Latini, F.; Lelli, G.; Monetti, Cinzia; Saletti, Andrea; Schivalocchi, R.; Seraceni, Silvia; Tola, Maria Rosalia; Urbini, Benedetta; Giorgi, Carlotta; Montanari, E.; Cerasti, Davide; Crafa, Pellegrino; Dascola, I.; Florindo, I.; Giombelli, E.; Mazza, S.; Ramponi, V.; Servadei, F.; Silini, E. M.; Torelli, P.; Immovilli, Paolo; Morelli, N.; Vanzo, C.; Nobile, C.

In: Neurological Sciences, 02.11.2016, p. 1-8.

Research output: Contribution to journalArticle

Baldin, E, Testoni, S, de Pasqua, S, Ferro, S, Albani, F, Baruzzi, A, Dalessandro, R, Baruzzi, A, Albani, F, Calbucci, F, D’Alessandro, R, Michelucci, R, Brandes, A, Eusebi, V, Ceruti, S, Fainardi, E, Tamarozzi, R, Emiliani, E, Cavallo, M, Franceschi, E, Tosoni, A, Cavallo, M, Fiorica, F, Valentini, A, Depenni, R, Mucciarini, C, Crisi, G, Sasso, E, Biasini, C, Cavanna, L, Guidetti, D, Marcello, N, Pisanello, A, Cremonini, A, Guiducci, G, de Pasqua, S, Testoni, S, Agati, R, Ambrosetto, G, Bacci, A, Baldin, E, Baldrati, A, Barbieri, E, Bartolini, S, Bellavista, E, Bisulli, F, Bonora, E, Bunkheila, F, Carelli, V, Crisci, M, Dall’Occa, P, Ferro, S, Franceschi, C, Frezza, G, Grasso, V, Leonardi, M, Mostacci, B, Palandri, G, Pasini, E, Pastore Trossello, M, Poggi, R, Riguzzi, P, Rinaldi, R, Rizzi, S, Romeo, G, Spagnolli, F, Tinuper, P, Trocino, C, Dall'Agata, M, Faedi, M, Frattarelli, M, Gentili, G, Giovannini, A, Iorio, P, Pasquini, U, Galletti, G, Guidi, C, Neri, W, Patuelli, A, Strumia, S, Casmiro, M, Gamboni, A, Rasi, F, Cruciani, G, Cenni, P, Dazzi, C, Guidi, AR, Zumaglini, F, Amadori, A, Pasini, G, Pasquinelli, M, Pasquini, E, Polselli, A, Ravasio, A, Viti, B, Sintini, M, Ariatti, A, Bertolini, F, Bigliardi, G, Carpeggiani, P, Cavalleri, F, Meletti, S, Nichelli, P, Pettorelli, E, Pinna, G, Zunarelli, E, Artioli, F, Bernardini, I, Costa, M, Greco, G, Guerzoni, R, Stucchi, C, Iaccarino, C, Ragazzi, M, Rizzi, R, Zuccoli, G, Api, P, Cartei, F, Fallica, E, Granieri, E, Latini, F, Lelli, G, Monetti, C, Saletti, A, Schivalocchi, R, Seraceni, S, Tola, MR, Urbini, B, Giorgi, C, Montanari, E, Cerasti, D, Crafa, P, Dascola, I, Florindo, I, Giombelli, E, Mazza, S, Ramponi, V, Servadei, F, Silini, EM, Torelli, P, Immovilli, P, Morelli, N, Vanzo, C & Nobile, C 2016, 'Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy', Neurological Sciences, pp. 1-8. https://doi.org/10.1007/s10072-016-2747-y
Baldin, Elisa ; Testoni, S. ; de Pasqua, S. ; Ferro, Salvatore ; Albani, Fiorenzo ; Baruzzi, Agostino ; Dalessandro, Roberto ; Baruzzi, A. ; Albani, F. ; Calbucci, F. ; D’Alessandro, R. ; Michelucci, Roberto ; Brandes, A. ; Eusebi, V. ; Ceruti, S. ; Fainardi, Enrico ; Tamarozzi, R. ; Emiliani, Ermanno ; Cavallo, Michele ; Franceschi, Enrico ; Tosoni, Alicia ; Cavallo, M. ; Fiorica, F. ; Valentini, A. ; Depenni, R. ; Mucciarini, C. ; Crisi, Girolamo ; Sasso, E. ; Biasini, Claudia ; Cavanna, Luigi ; Guidetti, D. ; Marcello, N. ; Pisanello, Anna ; Cremonini, Anna ; Guiducci, G. ; de Pasqua, S. ; Testoni, S. ; Agati, Raffaele ; Ambrosetto, G. ; Bacci, Antonella ; Baldin, Elisa ; Baldrati, A. ; Barbieri, Eveline ; Bartolini, Stefania ; Bellavista, Elena ; Bisulli, Francesca ; Bonora, Elena ; Bunkheila, F. ; Carelli, V. ; Crisci, Mauro ; Dall’Occa, P. ; Ferro, Salvatore ; Franceschi, Claudio ; Frezza, Giampiero ; Grasso, V. ; Leonardi, Marco ; Mostacci, Barbara ; Palandri, G. ; Pasini, Elena ; Pastore Trossello, M. ; Poggi, R. ; Riguzzi, Patrizia ; Rinaldi, R. ; Rizzi, S. ; Romeo, G. ; Spagnolli, F. ; Tinuper, P. ; Trocino, C. ; Dall'Agata, Monia ; Faedi, M. ; Frattarelli, Massimo ; Gentili, G. ; Giovannini, A. ; Iorio, P. ; Pasquini, U. ; Galletti, G. ; Guidi, Carlo ; Neri, Walter ; Patuelli, A. ; Strumia, S. ; Casmiro, M. ; Gamboni, A. ; Rasi, Fabrizio ; Cruciani, G. ; Cenni, P. ; Dazzi, C. ; Guidi, A. R. ; Zumaglini, Federica ; Amadori, Andrea ; Pasini, G. ; Pasquinelli, M. ; Pasquini, Ernesto ; Polselli, Antonio ; Ravasio, Alessandro ; Viti, B. ; Sintini, M. ; Ariatti, A. ; Bertolini, Francesco ; Bigliardi, G. ; Carpeggiani, Paolo ; Cavalleri, F. ; Meletti, S. ; Nichelli, Paolo ; Pettorelli, E. ; Pinna, GianPietro ; Zunarelli, E. ; Artioli, F. ; Bernardini, I. ; Costa, M. ; Greco, G. ; Guerzoni, R. ; Stucchi, C. ; Iaccarino, C. ; Ragazzi, Moira ; Rizzi, R. ; Zuccoli, Giulio ; Api, P. ; Cartei, F. ; Fallica, E. ; Granieri, Enrico ; Latini, F. ; Lelli, G. ; Monetti, Cinzia ; Saletti, Andrea ; Schivalocchi, R. ; Seraceni, Silvia ; Tola, Maria Rosalia ; Urbini, Benedetta ; Giorgi, Carlotta ; Montanari, E. ; Cerasti, Davide ; Crafa, Pellegrino ; Dascola, I. ; Florindo, I. ; Giombelli, E. ; Mazza, S. ; Ramponi, V. ; Servadei, F. ; Silini, E. M. ; Torelli, P. ; Immovilli, Paolo ; Morelli, N. ; Vanzo, C. ; Nobile, C. / Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy. In: Neurological Sciences. 2016 ; pp. 1-8.
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title = "Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy",
abstract = "Incidence of neuroepithelial Primary Brain Tumors (nPBT) varies, ranging from 7.3 to 11.6 cases/100,000/year across Europe. We present incidence and survival of nPBT in the Emilia-Romagna region (ER), Italy. This study is the largest in Southern Europe. Specialists in neurosurgery, neurology, neuroradiology, oncology, radiotherapy, genetics, and pathology of ER notified all suspected nPBT adult cases residing in ER (4,337,966 inhabitants) observed during 2009. Furthermore, through ICD-9 discharge codes, we identified and reviewed all possible cases. Neuroepithelial PBT diagnosis was based on histological or radiological findings. We included 400 incident nPBT cases, of which 102 (25{\%}) were retrospectively identified. These latter were significantly older. The standardized incidence was 10.5/100,000/year (95{\%} CI 9.4–11.5), higher for men. It was 9.2/100,000/year (95{\%} CI 8.3–10.2) for astrocytic tumors, 0.6/100,000/year (95{\%} CI 0.4–0.9) for oligodendroglial tumors, and 7.1 (95{\%} CI 6.3–8.0) for glioblastoma (GBM). Among GBM patients, median survival was 249 days if prospectively identified vs. 132 days when identified through ICD-9 codes (p < 0.0001). The incidence of nPBT in the ER region is among the highest in the literature. Older patients were more likely to escape an active surveillance system. This should be considered when comparing incidence rates across studies, giving the increasing number of elderly people in the general population.",
keywords = "Epidemiology, Glioblastoma, Incidence rate, Primary brain tumors, Survival",
author = "Elisa Baldin and S. Testoni and {de Pasqua}, S. and Salvatore Ferro and Fiorenzo Albani and Agostino Baruzzi and Roberto Dalessandro and A. Baruzzi and F. Albani and F. Calbucci and R. D’Alessandro and Roberto Michelucci and A. Brandes and V. Eusebi and S. Ceruti and Enrico Fainardi and R. Tamarozzi and Ermanno Emiliani and Michele Cavallo and Enrico Franceschi and Alicia Tosoni and M. Cavallo and F. Fiorica and A. Valentini and R. Depenni and C. Mucciarini and Girolamo Crisi and E. Sasso and Claudia Biasini and Luigi Cavanna and D. Guidetti and N. Marcello and Anna Pisanello and Anna Cremonini and G. Guiducci and {de Pasqua}, S. and S. Testoni and Raffaele Agati and G. Ambrosetto and Antonella Bacci and Elisa Baldin and A. Baldrati and Eveline Barbieri and Stefania Bartolini and Elena Bellavista and Francesca Bisulli and Elena Bonora and F. Bunkheila and V. Carelli and Mauro Crisci and P. Dall’Occa and Salvatore Ferro and Claudio Franceschi and Giampiero Frezza and V. Grasso and Marco Leonardi and Barbara Mostacci and G. Palandri and Elena Pasini and {Pastore Trossello}, M. and R. Poggi and Patrizia Riguzzi and R. Rinaldi and S. Rizzi and G. Romeo and F. Spagnolli and P. Tinuper and C. Trocino and Monia Dall'Agata and M. Faedi and Massimo Frattarelli and G. Gentili and A. Giovannini and P. Iorio and U. Pasquini and G. Galletti and Carlo Guidi and Walter Neri and A. Patuelli and S. Strumia and M. Casmiro and A. Gamboni and Fabrizio Rasi and G. Cruciani and P. Cenni and C. Dazzi and Guidi, {A. R.} and Federica Zumaglini and Andrea Amadori and G. Pasini and M. Pasquinelli and Ernesto Pasquini and Antonio Polselli and Alessandro Ravasio and B. Viti and M. Sintini and A. Ariatti and Francesco Bertolini and G. Bigliardi and Paolo Carpeggiani and F. Cavalleri and S. Meletti and Paolo Nichelli and E. Pettorelli and GianPietro Pinna and E. Zunarelli and F. Artioli and I. Bernardini and M. Costa and G. Greco and R. Guerzoni and C. Stucchi and C. Iaccarino and Moira Ragazzi and R. Rizzi and Giulio Zuccoli and P. Api and F. Cartei and E. Fallica and Enrico Granieri and F. Latini and G. Lelli and Cinzia Monetti and Andrea Saletti and R. Schivalocchi and Silvia Seraceni and Tola, {Maria Rosalia} and Benedetta Urbini and Carlotta Giorgi and E. Montanari and Davide Cerasti and Pellegrino Crafa and I. Dascola and I. Florindo and E. Giombelli and S. Mazza and V. Ramponi and F. Servadei and Silini, {E. M.} and P. Torelli and Paolo Immovilli and N. Morelli and C. Vanzo and C. Nobile",
year = "2016",
month = "11",
day = "2",
doi = "10.1007/s10072-016-2747-y",
language = "English",
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journal = "Neurological Sciences",
issn = "1590-1874",
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TY - JOUR

T1 - Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy

AU - Baldin, Elisa

AU - Testoni, S.

AU - de Pasqua, S.

AU - Ferro, Salvatore

AU - Albani, Fiorenzo

AU - Baruzzi, Agostino

AU - Dalessandro, Roberto

AU - Baruzzi, A.

AU - Albani, F.

AU - Calbucci, F.

AU - D’Alessandro, R.

AU - Michelucci, Roberto

AU - Brandes, A.

AU - Eusebi, V.

AU - Ceruti, S.

AU - Fainardi, Enrico

AU - Tamarozzi, R.

AU - Emiliani, Ermanno

AU - Cavallo, Michele

AU - Franceschi, Enrico

AU - Tosoni, Alicia

AU - Cavallo, M.

AU - Fiorica, F.

AU - Valentini, A.

AU - Depenni, R.

AU - Mucciarini, C.

AU - Crisi, Girolamo

AU - Sasso, E.

AU - Biasini, Claudia

AU - Cavanna, Luigi

AU - Guidetti, D.

AU - Marcello, N.

AU - Pisanello, Anna

AU - Cremonini, Anna

AU - Guiducci, G.

AU - de Pasqua, S.

AU - Testoni, S.

AU - Agati, Raffaele

AU - Ambrosetto, G.

AU - Bacci, Antonella

AU - Baldin, Elisa

AU - Baldrati, A.

AU - Barbieri, Eveline

AU - Bartolini, Stefania

AU - Bellavista, Elena

AU - Bisulli, Francesca

AU - Bonora, Elena

AU - Bunkheila, F.

AU - Carelli, V.

AU - Crisci, Mauro

AU - Dall’Occa, P.

AU - Ferro, Salvatore

AU - Franceschi, Claudio

AU - Frezza, Giampiero

AU - Grasso, V.

AU - Leonardi, Marco

AU - Mostacci, Barbara

AU - Palandri, G.

AU - Pasini, Elena

AU - Pastore Trossello, M.

AU - Poggi, R.

AU - Riguzzi, Patrizia

AU - Rinaldi, R.

AU - Rizzi, S.

AU - Romeo, G.

AU - Spagnolli, F.

AU - Tinuper, P.

AU - Trocino, C.

AU - Dall'Agata, Monia

AU - Faedi, M.

AU - Frattarelli, Massimo

AU - Gentili, G.

AU - Giovannini, A.

AU - Iorio, P.

AU - Pasquini, U.

AU - Galletti, G.

AU - Guidi, Carlo

AU - Neri, Walter

AU - Patuelli, A.

AU - Strumia, S.

AU - Casmiro, M.

AU - Gamboni, A.

AU - Rasi, Fabrizio

AU - Cruciani, G.

AU - Cenni, P.

AU - Dazzi, C.

AU - Guidi, A. R.

AU - Zumaglini, Federica

AU - Amadori, Andrea

AU - Pasini, G.

AU - Pasquinelli, M.

AU - Pasquini, Ernesto

AU - Polselli, Antonio

AU - Ravasio, Alessandro

AU - Viti, B.

AU - Sintini, M.

AU - Ariatti, A.

AU - Bertolini, Francesco

AU - Bigliardi, G.

AU - Carpeggiani, Paolo

AU - Cavalleri, F.

AU - Meletti, S.

AU - Nichelli, Paolo

AU - Pettorelli, E.

AU - Pinna, GianPietro

AU - Zunarelli, E.

AU - Artioli, F.

AU - Bernardini, I.

AU - Costa, M.

AU - Greco, G.

AU - Guerzoni, R.

AU - Stucchi, C.

AU - Iaccarino, C.

AU - Ragazzi, Moira

AU - Rizzi, R.

AU - Zuccoli, Giulio

AU - Api, P.

AU - Cartei, F.

AU - Fallica, E.

AU - Granieri, Enrico

AU - Latini, F.

AU - Lelli, G.

AU - Monetti, Cinzia

AU - Saletti, Andrea

AU - Schivalocchi, R.

AU - Seraceni, Silvia

AU - Tola, Maria Rosalia

AU - Urbini, Benedetta

AU - Giorgi, Carlotta

AU - Montanari, E.

AU - Cerasti, Davide

AU - Crafa, Pellegrino

AU - Dascola, I.

AU - Florindo, I.

AU - Giombelli, E.

AU - Mazza, S.

AU - Ramponi, V.

AU - Servadei, F.

AU - Silini, E. M.

AU - Torelli, P.

AU - Immovilli, Paolo

AU - Morelli, N.

AU - Vanzo, C.

AU - Nobile, C.

PY - 2016/11/2

Y1 - 2016/11/2

N2 - Incidence of neuroepithelial Primary Brain Tumors (nPBT) varies, ranging from 7.3 to 11.6 cases/100,000/year across Europe. We present incidence and survival of nPBT in the Emilia-Romagna region (ER), Italy. This study is the largest in Southern Europe. Specialists in neurosurgery, neurology, neuroradiology, oncology, radiotherapy, genetics, and pathology of ER notified all suspected nPBT adult cases residing in ER (4,337,966 inhabitants) observed during 2009. Furthermore, through ICD-9 discharge codes, we identified and reviewed all possible cases. Neuroepithelial PBT diagnosis was based on histological or radiological findings. We included 400 incident nPBT cases, of which 102 (25%) were retrospectively identified. These latter were significantly older. The standardized incidence was 10.5/100,000/year (95% CI 9.4–11.5), higher for men. It was 9.2/100,000/year (95% CI 8.3–10.2) for astrocytic tumors, 0.6/100,000/year (95% CI 0.4–0.9) for oligodendroglial tumors, and 7.1 (95% CI 6.3–8.0) for glioblastoma (GBM). Among GBM patients, median survival was 249 days if prospectively identified vs. 132 days when identified through ICD-9 codes (p < 0.0001). The incidence of nPBT in the ER region is among the highest in the literature. Older patients were more likely to escape an active surveillance system. This should be considered when comparing incidence rates across studies, giving the increasing number of elderly people in the general population.

AB - Incidence of neuroepithelial Primary Brain Tumors (nPBT) varies, ranging from 7.3 to 11.6 cases/100,000/year across Europe. We present incidence and survival of nPBT in the Emilia-Romagna region (ER), Italy. This study is the largest in Southern Europe. Specialists in neurosurgery, neurology, neuroradiology, oncology, radiotherapy, genetics, and pathology of ER notified all suspected nPBT adult cases residing in ER (4,337,966 inhabitants) observed during 2009. Furthermore, through ICD-9 discharge codes, we identified and reviewed all possible cases. Neuroepithelial PBT diagnosis was based on histological or radiological findings. We included 400 incident nPBT cases, of which 102 (25%) were retrospectively identified. These latter were significantly older. The standardized incidence was 10.5/100,000/year (95% CI 9.4–11.5), higher for men. It was 9.2/100,000/year (95% CI 8.3–10.2) for astrocytic tumors, 0.6/100,000/year (95% CI 0.4–0.9) for oligodendroglial tumors, and 7.1 (95% CI 6.3–8.0) for glioblastoma (GBM). Among GBM patients, median survival was 249 days if prospectively identified vs. 132 days when identified through ICD-9 codes (p < 0.0001). The incidence of nPBT in the ER region is among the highest in the literature. Older patients were more likely to escape an active surveillance system. This should be considered when comparing incidence rates across studies, giving the increasing number of elderly people in the general population.

KW - Epidemiology

KW - Glioblastoma

KW - Incidence rate

KW - Primary brain tumors

KW - Survival

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UR - http://www.scopus.com/inward/citedby.url?scp=84994246305&partnerID=8YFLogxK

U2 - 10.1007/s10072-016-2747-y

DO - 10.1007/s10072-016-2747-y

M3 - Article

SP - 1

EP - 8

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

ER -