Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy

Elisa Baldin, S. Testoni, S. de Pasqua, Salvatore Ferro, Fiorenzo Albani, Agostino Baruzzi, Roberto Dalessandro, A. Baruzzi, F. Albani, F. Calbucci, R. D’Alessandro, Roberto Michelucci, A. Brandes, V. Eusebi, S. Ceruti, Enrico Fainardi, R. Tamarozzi, Ermanno Emiliani, Michele Cavallo, Enrico FranceschiAlicia Tosoni, M. Cavallo, F. Fiorica, A. Valentini, R. Depenni, C. Mucciarini, Girolamo Crisi, E. Sasso, Claudia Biasini, Luigi Cavanna, D. Guidetti, N. Marcello, Anna Pisanello, Anna Cremonini, G. Guiducci, S. de Pasqua, S. Testoni, Raffaele Agati, G. Ambrosetto, Antonella Bacci, Elisa Baldin, A. Baldrati, Eveline Barbieri, Stefania Bartolini, Elena Bellavista, Francesca Bisulli, Elena Bonora, F. Bunkheila, V. Carelli, Mauro Crisci, P. Dall’Occa, Salvatore Ferro, Claudio Franceschi, Giampiero Frezza, V. Grasso, Marco Leonardi, Barbara Mostacci, G. Palandri, Elena Pasini, M. Pastore Trossello, R. Poggi, Patrizia Riguzzi, R. Rinaldi, S. Rizzi, G. Romeo, F. Spagnolli, P. Tinuper, C. Trocino, Monia Dall'Agata, M. Faedi, Massimo Frattarelli, G. Gentili, A. Giovannini, P. Iorio, U. Pasquini, G. Galletti, Carlo Guidi, Walter Neri, A. Patuelli, S. Strumia, M. Casmiro, A. Gamboni, Fabrizio Rasi, G. Cruciani, P. Cenni, C. Dazzi, A. R. Guidi, Federica Zumaglini, Andrea Amadori, G. Pasini, M. Pasquinelli, Ernesto Pasquini, Antonio Polselli, Alessandro Ravasio, B. Viti, M. Sintini, A. Ariatti, Francesco Bertolini, G. Bigliardi, Paolo Carpeggiani, F. Cavalleri, S. Meletti, Paolo Nichelli, E. Pettorelli, GianPietro Pinna, E. Zunarelli, F. Artioli, I. Bernardini, M. Costa, G. Greco, R. Guerzoni, C. Stucchi, C. Iaccarino, Moira Ragazzi, R. Rizzi, Giulio Zuccoli, P. Api, F. Cartei, E. Fallica, Enrico Granieri, F. Latini, G. Lelli, Cinzia Monetti, Andrea Saletti, R. Schivalocchi, Silvia Seraceni, Maria Rosalia Tola, Benedetta Urbini, Carlotta Giorgi, E. Montanari, Davide Cerasti, Pellegrino Crafa, I. Dascola, I. Florindo, E. Giombelli, S. Mazza, V. Ramponi, F. Servadei, E. M. Silini, P. Torelli, Paolo Immovilli, N. Morelli, C. Vanzo, C. Nobile

Research output: Contribution to journalArticle

Abstract

Incidence of neuroepithelial Primary Brain Tumors (nPBT) varies, ranging from 7.3 to 11.6 cases/100,000/year across Europe. We present incidence and survival of nPBT in the Emilia-Romagna region (ER), Italy. This study is the largest in Southern Europe. Specialists in neurosurgery, neurology, neuroradiology, oncology, radiotherapy, genetics, and pathology of ER notified all suspected nPBT adult cases residing in ER (4,337,966 inhabitants) observed during 2009. Furthermore, through ICD-9 discharge codes, we identified and reviewed all possible cases. Neuroepithelial PBT diagnosis was based on histological or radiological findings. We included 400 incident nPBT cases, of which 102 (25%) were retrospectively identified. These latter were significantly older. The standardized incidence was 10.5/100,000/year (95% CI 9.4–11.5), higher for men. It was 9.2/100,000/year (95% CI 8.3–10.2) for astrocytic tumors, 0.6/100,000/year (95% CI 0.4–0.9) for oligodendroglial tumors, and 7.1 (95% CI 6.3–8.0) for glioblastoma (GBM). Among GBM patients, median survival was 249 days if prospectively identified vs. 132 days when identified through ICD-9 codes (p < 0.0001). The incidence of nPBT in the ER region is among the highest in the literature. Older patients were more likely to escape an active surveillance system. This should be considered when comparing incidence rates across studies, giving the increasing number of elderly people in the general population.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalNeurological Sciences
DOIs
Publication statusAccepted/In press - Nov 2 2016

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Keywords

  • Epidemiology
  • Glioblastoma
  • Incidence rate
  • Primary brain tumors
  • Survival

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Baldin, E., Testoni, S., de Pasqua, S., Ferro, S., Albani, F., Baruzzi, A., Dalessandro, R., Baruzzi, A., Albani, F., Calbucci, F., D’Alessandro, R., Michelucci, R., Brandes, A., Eusebi, V., Ceruti, S., Fainardi, E., Tamarozzi, R., Emiliani, E., Cavallo, M., ... Nobile, C. (Accepted/In press). Incidence of neuroepithelial primary brain tumors among adult population of Emilia-Romagna Region, Italy. Neurological Sciences, 1-8. https://doi.org/10.1007/s10072-016-2747-y