Incidenza di nuove fratture in donne con fratture vertebrali indotte dall'osteoporosi, visualizzate nelle proiezioni laterali della radiografia del torace

Translated title of the contribution: Incidence of new fractures in women with osteoporosis-induced vertebral fractures detected on routine lateral chest radiographs

F. Occhicone, C. C. Quattrocchi, N. Napoli, P. Dell'Aia, F. D'Agostino, P. Pozzilli, B. Beomonte Zobel

Research output: Contribution to journalArticle

Abstract

Purpose: Vertebral fractures represent one of the major complications of osteopororis. Diagnosis is followed by a pharmacological, interventional or surgical treatment. Up to day there are non practice guidelines for a screening evaluation of bone fractures in elderly and most of the fractures remain undiagnosed. We prospectively evaluated the prevalence of vertebral fractures on chest X-rays to determine the diagnostic and prognostic roles of chest X-ray in predicting new bone fractures 2 years after the initial radiogram. Materials and methods: Between March 2004 and October 2005, 4,045 women underwent chest X-ray in our radiology department for any indication. We identified 166 women with the presence of at least one vertebral fracture. A questionnaire was administered to these women to collect information about diagnosis of osteoporosis, history of malignancy, systemic diseases, osteoporosis-inducing drugs and pharmacological, radiological or surgical treatment received. Results: Out of the 166 women (age 73±10.5 years) with vertebral fractures, we interviewed 101 women; 13 had died and 52 were not found. Most of the patients were on menopause (97.1%, 98/101) with an average age of menopause of 48,2 years (±6 years). Among the patients on menopause, 15,8% (16/101) had undergone hysterectomy. All patients received a diagnosis of osteoporosis, which was reached with a chest X-ray report in 23.7% (24/101) of cases. A new skeletal fracture occurred in 20.5% (5/27) of patients receiving treatment against a frequency of 20.8% (16/74) in patients without treatment. No statistical difference was found between the groups (p = 0.374). Conclusions: Inadequate treatment may explain the lack of a substantial difference in new fracture risk between treated and untreated patients. For these reason we discuss about the evaluation of an adeguate therapeutic approaches in prevention of osteoporosis-induced fractures.

Translated title of the contributionIncidence of new fractures in women with osteoporosis-induced vertebral fractures detected on routine lateral chest radiographs
Original languageItalian
Pages (from-to)815-825
Number of pages11
JournalRadiologia Medica
Volume115
Issue number5
DOIs
Publication statusPublished - Aug 2010

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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