Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: A 12-year experience at a single Italian institution

R. Haupt, M. Romanengo, T. Fears, C. Viscoli, E. Castagnola

Research output: Contribution to journalArticlepeer-review

Abstract

We carried out a retrospective study on the infection rate - in episodes per 100 person months at risk (p/m/r) - of septicaemia and invasive mycoses in children with solid tumours treated at a single institution between 1985 and 1996. Among 982 patients, accounting for 8108 p/m/r, 257 infectious episodes were documented, for an infection rate of 3.2. The infection rate for 'intensive' treatment was greater than that for 'less intensive' treatments, 3.7 compared with 0.5, respectively; P <0.001. 58% of infectious episodes were associated with neutropenia, 22% were megatherapy-related, and 39% were related to central venous catheter (CVC), while in 13% of the episodes no risk factor was identified. Of the episodes, single organism Gram-positive bacteraemias accounted for 62%, single organism Gram-negative for 23%, multiple organism bacteraemias for 7%, invasive mycoses for 4%, and isolated fungaemias for 4%. The infection rate for Gram-positive organisms decreased significantly over time (-5.9% per year; P <0.01), but increased for the Gram-negative organisms ( + 3.4% per year; P = 0.4). This study demonstrates that the risk of bacteraemia increases in parallel with the treatment intensity, and that a considerable number of children with solid tumours develop bacteraemia in the absence of an identifiable risk factor.

Original languageEnglish
Pages (from-to)2413-2419
Number of pages7
JournalEuropean Journal of Cancer
Volume37
Issue number18
DOIs
Publication statusPublished - 2001

Keywords

  • Bacterial infections
  • Mycoses
  • Paediatrics
  • Solid tumour

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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