INCIDENZA DI SIEROCONVERSIONE PER GLI ANTICORPI CONTRO IL VIRUS DELL'EPATITE C (HCV) IN PAZIENTI EMODIALIZZATI CRONICI: STUDIO PROSPETTIVO

Translated title of the contribution: Incidence of seroconversion for hepatitis C virus (HCV) in chronic hemodialysis (HD) patients: A prospective study

F. Fabrizi, I. Guarnori, G. Lunghi, S. Di Filippo, M. Crepaldi, L. Raffaele, G. Erba, A. Pagano, F. Locatelli

Research output: Contribution to journalArticle

Abstract

We conducted a prospective study in hemodialyzed patients of our department to evaluate the incidence of seroconversion for HCV in this high-risk group; 165 patients were seronegative and 53 seropositive for anti-HCV antibodies at the start of this study. During the average follow-up period of 27.8 months, one patient developed anti-HCV antibodies late in the study, while the other 154 patients remained seronegative through the follow-up. Our results show a very low incidence of HCV-seropositivity (0.26% per year) after implementation of our operative protocol including 'universal precautions' and other infection control procedures. Once infected, there is no disappearance rate of anti-HCV. The 4-RIBA results did not change during the follow-up period. HCV-RNA was detected in 4 of 27 anti-HCV positive patients tested by a RT-PCR which uses primers from the 5' non coding region (5' NCR) of the HCV genoma. The exact route of transmission of HCV among HD patients needs future investigation; long-term prospective studies are necessary to confirm these results.

Translated title of the contributionIncidence of seroconversion for hepatitis C virus (HCV) in chronic hemodialysis (HD) patients: A prospective study
Original languageItalian
Pages (from-to)401-407
Number of pages7
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume11
Issue number5
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Nephrology

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