Incidence, Patterns, and Associations Between Dual-Antiplatelet Therapy Cessation and Risk for Adverse Events Among Patients With and Without Diabetes Mellitus Receiving Drug-Eluting Stents: Results From the PARIS Registry

Michela Faggioni, U Baber, S Sartori, G Giustino, DJ Cohen, TD Henry, S Farhan, C Ariti, G Dangas, M Gibson, D Giacoppo, MW Krucoff, Melissa Aquino, J Chandrasekhar, DJ Moliterno, A Colombo, B Vogel, A Chieffo, AS Kini, B WitzenbichlerG Weisz, PG Steg, S Pocock, R Mehran

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives The aim of this study was to examine the frequency and clinical impact of different cessation patterns of dual-antiplatelet therapy (DAPT) after percutaneous coronary intervention with drug-eluting stents among patients with and those without diabetes mellitus (DM). Background Early DAPT suspension after percutaneous coronary intervention increases the risk for major adverse cardiac events. However, temporal variability in risk and relation to DAPT cessation patterns among patients with DM remain unclear. Methods Using data from the PARIS (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients) registry, 1,430 patients with DM (34%) and 2,777 without DM (66%) treated with drug-eluting stents were identified. DAPT cessation modes were classified as temporary interruption (
Original languageEnglish
Pages (from-to)645-654
Number of pages10
JournalJACC: Cardiovascular Interventions
Volume10
Issue number7
DOIs
Publication statusPublished - 2017

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