Incidence, predictors, and impact on prognosis of systolic pulmonary artery pressure and its improvement after transcatheter aortic valve implantation: A multicenter registry

Fabrizio D'Ascenzo, Federico Conrotto, Stefano Salizzoni, Marco Luciano Rossi, Freek Nijhoff, Valeria Gasparetto, Marco Barbanti, Marco Mennuni, Pierluigi Omedè, Walter Grosso Marra, Giorgio Quadri, Francesca Giordana, Corrado Tamburino, Giuseppe Tarantini, Patrizia Presbitero, Massimo Napodanno, Pieter Stella, Giuseppe Biondi-Zoccai, Pierfrancesco Agostoni, Maurizio D'amicoClaudio Moretti, Mauro Rinaldi, Sebastiano Marra, Fiorenzo Gaita

Research output: Contribution to journalArticle

Abstract

AIMS: Elevated values of systolic pulmonary artery pressure (sPAP) represent a common finding in patients with aortic stenosis and severe left ventricular hypertrophy. Prognostic impact of sPAP and its potential improvement after transcatheter aortic valve implantation (TAVI) remains to be determined. METHODS AND RESULTS: This is a multicenter retrospective registry in five European institutions. All consecutive patients undergoing TAVI were enrolled, and divided into two groups according to sPAP evaluated with echocardiography: ≤40 mm Hg and >40 mm Hg. All-cause mortality at follow-up of at least 1 year was the primary endpoint, while 30-day mortality, periprocedural complications, myocardial infarction, stroke, and reintervention rates at follow-up were the secondary endpoints. Among 674 patients enrolled, a total of 319 (47%) had sPAP >40 mm Hg. This was associated with higher mortality at 30 days (4.5% vs 8.5%; P≤.03) and at a median follow-up of 477 days (17% vs 26%; P≤.03). Improvement of sPAP was reported in 113 patients (27%), occurring more frequently in absence of moderate or severe mitral regurgitation and of right ventricle dysfunction. With multivariate adjustment, reduced renal function, insulin-dependent diabetes mellitus, and sPAP >40 mm Hg were independent predictors of all-cause mortality, improvement in sPAP values was related to a better survival, while ejection fraction was not. CONCLUSION: Elevated values of sPAP represent a common finding in patients undergoing TAVI. This parameter, along with its improvement, may be used to stratify risk and determine prognosis for patients undergoing TAVI.

Original languageEnglish
Pages (from-to)114-119
Number of pages6
JournalJournal of Invasive Cardiology
Volume27
Issue number2
Publication statusPublished - Feb 1 2015

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Keywords

  • aortic stenosis
  • left ventricular hypertrophy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

D'Ascenzo, F., Conrotto, F., Salizzoni, S., Rossi, M. L., Nijhoff, F., Gasparetto, V., Barbanti, M., Mennuni, M., Omedè, P., Grosso Marra, W., Quadri, G., Giordana, F., Tamburino, C., Tarantini, G., Presbitero, P., Napodanno, M., Stella, P., Biondi-Zoccai, G., Agostoni, P., ... Gaita, F. (2015). Incidence, predictors, and impact on prognosis of systolic pulmonary artery pressure and its improvement after transcatheter aortic valve implantation: A multicenter registry. Journal of Invasive Cardiology, 27(2), 114-119.