Incidence rates of leukemias, lymphomas and myelomas in Italy: Geographic distribution and NHL histotypes

Giovanna Masala, Simonetta Di Lollo, Cosimo Picoco, Paolo Crosignani, Vittorio Demicheli, Arabella Fontana, Ilaria Funtó, Lucia Miligi, Oriana Nanni, Alessandra Papucci, Valerie Ramazzotti, Stefania Rodella, Emanuele Stagnaro, Rosario Tumino, Clotilde Viganó, Carla Vindigni, Adele Seniori Costantini, Paolo Vineis

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The annual incidence of non-Hodgkin's lymphomas is increasing by 3 to 4% in different parts of the developed world, while rates for Hodgkin's disease, myelomas and leukemias are more stable. In the case of this group of malignancies, hypothesis generation on risk factors has been limited by the use of the ICD classification in mortality and incidence statistics. We have computed incidence rates in different Italian areas after careful re-classification of diagnoses, and considering specific histotypes (Working Formulation for NHL, Rye's classification for HD). While no particularly interesting pattern is suggested for Hodgkin's disease (even after considering specific Rye subgroups), multiple myeloma and leukemias, for non-Hodgkin's lymphomas the high rate in one agricultural area (Forli) was mainly due to the A sub-group in the Working Formulation (low-grade). In a heavily industrialized area (Varese), the high incidence rate was at least partly explained by a higher proportion of cases classified in the G sub-group (intermediate grade). Excesses of non-Hodgkin's lymphomas have been observed in populations exposed to phenoxy-acetic-acid herbicides, to insecticides and to organic solvents. One can hypothesize that different risk factors act on different stem cells and induce lymphoid malignancies belonging to different histologic sub-types.

Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalInternational Journal of Cancer
Volume68
Issue number2
DOIs
Publication statusPublished - 1996

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Italy
Lymphoma
Leukemia
Non-Hodgkin's Lymphoma
Incidence
Hodgkin Disease
Lymphoid Progenitor Cells
Herbicides
Insecticides
Multiple Myeloma
Acetic Acid
Neoplasms
Mortality
Population
Secale

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Incidence rates of leukemias, lymphomas and myelomas in Italy : Geographic distribution and NHL histotypes. / Masala, Giovanna; Di Lollo, Simonetta; Picoco, Cosimo; Crosignani, Paolo; Demicheli, Vittorio; Fontana, Arabella; Funtó, Ilaria; Miligi, Lucia; Nanni, Oriana; Papucci, Alessandra; Ramazzotti, Valerie; Rodella, Stefania; Stagnaro, Emanuele; Tumino, Rosario; Viganó, Clotilde; Vindigni, Carla; Seniori Costantini, Adele; Vineis, Paolo.

In: International Journal of Cancer, Vol. 68, No. 2, 1996, p. 156-159.

Research output: Contribution to journalArticle

Masala, G, Di Lollo, S, Picoco, C, Crosignani, P, Demicheli, V, Fontana, A, Funtó, I, Miligi, L, Nanni, O, Papucci, A, Ramazzotti, V, Rodella, S, Stagnaro, E, Tumino, R, Viganó, C, Vindigni, C, Seniori Costantini, A & Vineis, P 1996, 'Incidence rates of leukemias, lymphomas and myelomas in Italy: Geographic distribution and NHL histotypes', International Journal of Cancer, vol. 68, no. 2, pp. 156-159. https://doi.org/10.1002/(SICI)1097-0215(19961009)68:2<156::AID-IJC2>3.0.CO;2-X
Masala, Giovanna ; Di Lollo, Simonetta ; Picoco, Cosimo ; Crosignani, Paolo ; Demicheli, Vittorio ; Fontana, Arabella ; Funtó, Ilaria ; Miligi, Lucia ; Nanni, Oriana ; Papucci, Alessandra ; Ramazzotti, Valerie ; Rodella, Stefania ; Stagnaro, Emanuele ; Tumino, Rosario ; Viganó, Clotilde ; Vindigni, Carla ; Seniori Costantini, Adele ; Vineis, Paolo. / Incidence rates of leukemias, lymphomas and myelomas in Italy : Geographic distribution and NHL histotypes. In: International Journal of Cancer. 1996 ; Vol. 68, No. 2. pp. 156-159.
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AU - Crosignani, Paolo

AU - Demicheli, Vittorio

AU - Fontana, Arabella

AU - Funtó, Ilaria

AU - Miligi, Lucia

AU - Nanni, Oriana

AU - Papucci, Alessandra

AU - Ramazzotti, Valerie

AU - Rodella, Stefania

AU - Stagnaro, Emanuele

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AU - Vindigni, Carla

AU - Seniori Costantini, Adele

AU - Vineis, Paolo

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