Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation

L. Crucitti, R. Crocchiolo, C. Toffalori, B. Mazzi, R. Greco, A. Signori, F. Sizzano, L. Chiesa, E. Zino, M. T. Lupo Stanghellini, A. Assanelli, M. G. Carrabba, S. Marktel, M. Marcatti, C. Bordignon, C. Corti, M. Bernardi, J. Peccatori, C. Bonini, K. FleischhauerF. Ciceri, L. Vago

Research output: Contribution to journalArticle

Abstract

Genomic loss of the mismatched human leukocyte antigen (HLA) is a recently described mechanism of leukemia immune escape and relapse after allogeneic hematopoietic stem cell transplantation (HSCT). Here we first evaluated its incidence, risk factors and outcome in 233 consecutive transplants from partially HLA-mismatched related and unrelated donors (MMRD and MMUD, respectively). We documented 84 relapses, 23 of which with HLA loss. All the HLA loss relapses occurred after MMRD HSCT, and 2023 in patients with acute myeloid leukemia. Upon MMRD HSCT, HLA loss variants accounted for 33% of the relapses (2369), occurring later than their 'classical' counterparts (median: 307 vs 88 days, P

Original languageEnglish
Pages (from-to)1143-1152
Number of pages10
JournalLeukemia
Volume29
Issue number5
DOIs
Publication statusPublished - May 11 2015

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine
  • Medicine(all)

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    Crucitti, L., Crocchiolo, R., Toffalori, C., Mazzi, B., Greco, R., Signori, A., Sizzano, F., Chiesa, L., Zino, E., Lupo Stanghellini, M. T., Assanelli, A., Carrabba, M. G., Marktel, S., Marcatti, M., Bordignon, C., Corti, C., Bernardi, M., Peccatori, J., Bonini, C., ... Vago, L. (2015). Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation. Leukemia, 29(5), 1143-1152. https://doi.org/10.1038/leu.2014.314