Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

C. Girmenia, A. Bertaina, A. Piciocchi, K. Perruccio, A. Algarotti, A. Busca, C. Cattaneo, A. M. Raiola, S. Guidi, A. P. Iori, A. Candoni, G. Irrera, G. Milone, G. Marcacci, R. Scime, M. Musso, L. Cudillo, S. Sica, L. Castagna, P. CorradiniF. Marchesi, D. Pastore, E. P. Alessandrino, C. Annaloro, F. Ciceri, S. Santarone, L. Nassi, C. Farina, C. Viscoli, G. M. Rossolini, F. Bonifazi, A. Rambaldi, Gruppo Italiano Trapianto di Midollo Osseo (GITMO), Associazione Microbiologi Clinici Italiani (AMCLI)

Research output: Contribution to journalArticle

Abstract

Background: Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods: We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results: The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45-3.13; P
Original languageEnglish
Pages (from-to)1884-1896
Number of pages13
JournalClinical Infectious Diseases
Volume65
Issue number11
DOIs
Publication statusPublished - Nov 13 2017

    Fingerprint

Keywords

  • Gram negative bacteremia
  • epidemiology
  • multidrug resistance
  • stem cell transplant
  • survival

Cite this

Girmenia, C., Bertaina, A., Piciocchi, A., Perruccio, K., Algarotti, A., Busca, A., Cattaneo, C., Raiola, A. M., Guidi, S., Iori, A. P., Candoni, A., Irrera, G., Milone, G., Marcacci, G., Scime, R., Musso, M., Cudillo, L., Sica, S., Castagna, L., ... (AMCLI), A. M. C. I. (2017). Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey. Clinical Infectious Diseases, 65(11), 1884-1896. https://doi.org/10.1093/cid/cix690 [doi]