Incidence trends of colorectal cancer in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening

Manuel Zorzi, Lucia Mangone, Romano Sassatelli, Susanna Baracco, Mario Budroni, Marine Castaing, Claudia Cirilli, Rosanna Cusimano, M. Fusco, Adriano Giacomin, Paolo Giorgi Rossi, Carlo Naldoni, Fabio Pannozzo, Silvano Piffer, Antonella Puppo, Francesco Tisano, Marco Zappa, A. Azzoni, P. Baldazzi, N. CollinaP. Pandolfi, C. Petrucci, G. Gualandi, S. Sciacchitano, A. Ieni, F. Bella, A. Torrisi, M. Varvarà, A. C. Finarelli, P. Sassoli De Bianchi, P. Landi, S. Ferretti, V. Matarese, A. De Togni, C. Palmonari, A. Caldarella, E. Crocetti, G. Grazzini, G. Manneschi, P. Mantellini, D. Serraino, E. Bidoli, M. Taborelli, A. Gini, S. Virdone, C. Casella, M. Celesia, R. Cogno, E. Marani, S. Busco, E. Bernazza, S. Curatella, L. Macci, M. Rossi, G. Randi, B. Frammartino, A. Bonini, L. Filippazzi, C. Giubelli, R. Corradini, F. De Girolamo, K. Valla, R. Palombino, M. D'Orsi, M. Isernia, M. Fusco, F. M. Vitale, M. S. Adamo, R. Amodio, A. Brucculeri, A. Guttadauro, W. Mazzucco, P. Sgarzi, F. Bozzani, M. Zatelli, C. Zurlini, P. Caruana, E. Borciani, G. Gatti, R. Prazzoli, P. Seghini, C. Campari, E. Di Felice, C. Sacchettini, T. Cassetti, F. Falcini, S. Mancini, R. Vattiato, O. Giuliani, L. Caprara, R. Cesaraccio, O. Sechi, A. Madeddu, M. L. Contrino, A. Colanino Ziino, M. Russo, A. C. Fanetti, S. Maspero, E. Moroni, I. Cometti, M. Gentilini, G. De Pretis, P. Caciagli, R. Pertile, F. Bianconi, G. M. Masanotti, M. C. De Lio, S. Leite, B. U. Passamonti, A. P. Dei Tos, A. Rosano, D. Monetti, S. Guzzinati, S. Tognazzo

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

We utilised the IMPATTO study's archives to describe the 2000-2008 colorectal cancer (CRC) incidence rate trends in Italy, once screening programmes based on the faecal immunochemical test were implemented in different areas. Data on CRCs diagnosed in Italy from 2000 to 2008 in subjects aged 40-79 years were collected by 23 cancer registries. Incidence rate trends were evaluated as a whole and by macro-area (North-Centre and South-Islands), presence of a screening programme, sex, ten-year age class, anatomic site, stage at diagnosis, and pattern of diagnosis (screen-detected, non-screen-detected). The annual percent change (APC) of incidence rate trends, with 95% confidence intervals (95%CI), were computed. The study included 46,857 CRCs diagnosed in subjects aged 40-79 years, of which 2,806 were screendetected. The incidence rates in the North-Centre were higher than in the South and on the Islands. During the study period, screening programmes had been implemented only in the North-Centre and had a significant effect on incidence rates, with an initial sharp increase in incidence, followed by a decrease that started in the 3rd-4th years of screening. These incidence rate trends were exclusively due to modifications in the rates of stage I cases. After screening programmes started, incidence increased in all anatomic sites, particularly in the distal colon. The differential figures introduced by the implementation of screening programmes warrant a continuous surveillance of CRC incidence and mortality trends to monitor the impact of screening at a national level.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalEpidemiologia e prevenzione
Volume39
Issue number3
Publication statusPublished - May 1 2015

Fingerprint

Early Detection of Cancer
Italy
Colorectal Neoplasms
Incidence
Islands
Registries
Colon
Confidence Intervals
Mortality

Keywords

  • Colorectal cancer
  • Fecal immunochemical test
  • Incidence rates
  • Italy
  • Screening

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Incidence trends of colorectal cancer in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening. / Zorzi, Manuel; Mangone, Lucia; Sassatelli, Romano; Baracco, Susanna; Budroni, Mario; Castaing, Marine; Cirilli, Claudia; Cusimano, Rosanna; Fusco, M.; Giacomin, Adriano; Rossi, Paolo Giorgi; Naldoni, Carlo; Pannozzo, Fabio; Piffer, Silvano; Puppo, Antonella; Tisano, Francesco; Zappa, Marco; Azzoni, A.; Baldazzi, P.; Collina, N.; Pandolfi, P.; Petrucci, C.; Gualandi, G.; Sciacchitano, S.; Ieni, A.; Bella, F.; Torrisi, A.; Varvarà, M.; Finarelli, A. C.; De Bianchi, P. Sassoli; Landi, P.; Ferretti, S.; Matarese, V.; De Togni, A.; Palmonari, C.; Caldarella, A.; Crocetti, E.; Grazzini, G.; Manneschi, G.; Mantellini, P.; Serraino, D.; Bidoli, E.; Taborelli, M.; Gini, A.; Virdone, S.; Casella, C.; Celesia, M.; Cogno, R.; Marani, E.; Busco, S.; Bernazza, E.; Curatella, S.; Macci, L.; Rossi, M.; Randi, G.; Frammartino, B.; Bonini, A.; Filippazzi, L.; Giubelli, C.; Corradini, R.; De Girolamo, F.; Valla, K.; Palombino, R.; D'Orsi, M.; Isernia, M.; Fusco, M.; Vitale, F. M.; Adamo, M. S.; Amodio, R.; Brucculeri, A.; Guttadauro, A.; Mazzucco, W.; Sgarzi, P.; Bozzani, F.; Zatelli, M.; Zurlini, C.; Caruana, P.; Borciani, E.; Gatti, G.; Prazzoli, R.; Seghini, P.; Campari, C.; Di Felice, E.; Sacchettini, C.; Cassetti, T.; Falcini, F.; Mancini, S.; Vattiato, R.; Giuliani, O.; Caprara, L.; Cesaraccio, R.; Sechi, O.; Madeddu, A.; Contrino, M. L.; Colanino Ziino, A.; Russo, M.; Fanetti, A. C.; Maspero, S.; Moroni, E.; Cometti, I.; Gentilini, M.; De Pretis, G.; Caciagli, P.; Pertile, R.; Bianconi, F.; Masanotti, G. M.; De Lio, M. C.; Leite, S.; Passamonti, B. U.; Dei Tos, A. P.; Rosano, A.; Monetti, D.; Guzzinati, S.; Tognazzo, S.

In: Epidemiologia e prevenzione, Vol. 39, No. 3, 01.05.2015, p. 115-125.

Research output: Contribution to journalReview article

Zorzi, M, Mangone, L, Sassatelli, R, Baracco, S, Budroni, M, Castaing, M, Cirilli, C, Cusimano, R, Fusco, M, Giacomin, A, Rossi, PG, Naldoni, C, Pannozzo, F, Piffer, S, Puppo, A, Tisano, F, Zappa, M, Azzoni, A, Baldazzi, P, Collina, N, Pandolfi, P, Petrucci, C, Gualandi, G, Sciacchitano, S, Ieni, A, Bella, F, Torrisi, A, Varvarà, M, Finarelli, AC, De Bianchi, PS, Landi, P, Ferretti, S, Matarese, V, De Togni, A, Palmonari, C, Caldarella, A, Crocetti, E, Grazzini, G, Manneschi, G, Mantellini, P, Serraino, D, Bidoli, E, Taborelli, M, Gini, A, Virdone, S, Casella, C, Celesia, M, Cogno, R, Marani, E, Busco, S, Bernazza, E, Curatella, S, Macci, L, Rossi, M, Randi, G, Frammartino, B, Bonini, A, Filippazzi, L, Giubelli, C, Corradini, R, De Girolamo, F, Valla, K, Palombino, R, D'Orsi, M, Isernia, M, Fusco, M, Vitale, FM, Adamo, MS, Amodio, R, Brucculeri, A, Guttadauro, A, Mazzucco, W, Sgarzi, P, Bozzani, F, Zatelli, M, Zurlini, C, Caruana, P, Borciani, E, Gatti, G, Prazzoli, R, Seghini, P, Campari, C, Di Felice, E, Sacchettini, C, Cassetti, T, Falcini, F, Mancini, S, Vattiato, R, Giuliani, O, Caprara, L, Cesaraccio, R, Sechi, O, Madeddu, A, Contrino, ML, Colanino Ziino, A, Russo, M, Fanetti, AC, Maspero, S, Moroni, E, Cometti, I, Gentilini, M, De Pretis, G, Caciagli, P, Pertile, R, Bianconi, F, Masanotti, GM, De Lio, MC, Leite, S, Passamonti, BU, Dei Tos, AP, Rosano, A, Monetti, D, Guzzinati, S & Tognazzo, S 2015, 'Incidence trends of colorectal cancer in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening', Epidemiologia e prevenzione, vol. 39, no. 3, pp. 115-125.
Zorzi, Manuel ; Mangone, Lucia ; Sassatelli, Romano ; Baracco, Susanna ; Budroni, Mario ; Castaing, Marine ; Cirilli, Claudia ; Cusimano, Rosanna ; Fusco, M. ; Giacomin, Adriano ; Rossi, Paolo Giorgi ; Naldoni, Carlo ; Pannozzo, Fabio ; Piffer, Silvano ; Puppo, Antonella ; Tisano, Francesco ; Zappa, Marco ; Azzoni, A. ; Baldazzi, P. ; Collina, N. ; Pandolfi, P. ; Petrucci, C. ; Gualandi, G. ; Sciacchitano, S. ; Ieni, A. ; Bella, F. ; Torrisi, A. ; Varvarà, M. ; Finarelli, A. C. ; De Bianchi, P. Sassoli ; Landi, P. ; Ferretti, S. ; Matarese, V. ; De Togni, A. ; Palmonari, C. ; Caldarella, A. ; Crocetti, E. ; Grazzini, G. ; Manneschi, G. ; Mantellini, P. ; Serraino, D. ; Bidoli, E. ; Taborelli, M. ; Gini, A. ; Virdone, S. ; Casella, C. ; Celesia, M. ; Cogno, R. ; Marani, E. ; Busco, S. ; Bernazza, E. ; Curatella, S. ; Macci, L. ; Rossi, M. ; Randi, G. ; Frammartino, B. ; Bonini, A. ; Filippazzi, L. ; Giubelli, C. ; Corradini, R. ; De Girolamo, F. ; Valla, K. ; Palombino, R. ; D'Orsi, M. ; Isernia, M. ; Fusco, M. ; Vitale, F. M. ; Adamo, M. S. ; Amodio, R. ; Brucculeri, A. ; Guttadauro, A. ; Mazzucco, W. ; Sgarzi, P. ; Bozzani, F. ; Zatelli, M. ; Zurlini, C. ; Caruana, P. ; Borciani, E. ; Gatti, G. ; Prazzoli, R. ; Seghini, P. ; Campari, C. ; Di Felice, E. ; Sacchettini, C. ; Cassetti, T. ; Falcini, F. ; Mancini, S. ; Vattiato, R. ; Giuliani, O. ; Caprara, L. ; Cesaraccio, R. ; Sechi, O. ; Madeddu, A. ; Contrino, M. L. ; Colanino Ziino, A. ; Russo, M. ; Fanetti, A. C. ; Maspero, S. ; Moroni, E. ; Cometti, I. ; Gentilini, M. ; De Pretis, G. ; Caciagli, P. ; Pertile, R. ; Bianconi, F. ; Masanotti, G. M. ; De Lio, M. C. ; Leite, S. ; Passamonti, B. U. ; Dei Tos, A. P. ; Rosano, A. ; Monetti, D. ; Guzzinati, S. ; Tognazzo, S. / Incidence trends of colorectal cancer in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening. In: Epidemiologia e prevenzione. 2015 ; Vol. 39, No. 3. pp. 115-125.
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abstract = "We utilised the IMPATTO study's archives to describe the 2000-2008 colorectal cancer (CRC) incidence rate trends in Italy, once screening programmes based on the faecal immunochemical test were implemented in different areas. Data on CRCs diagnosed in Italy from 2000 to 2008 in subjects aged 40-79 years were collected by 23 cancer registries. Incidence rate trends were evaluated as a whole and by macro-area (North-Centre and South-Islands), presence of a screening programme, sex, ten-year age class, anatomic site, stage at diagnosis, and pattern of diagnosis (screen-detected, non-screen-detected). The annual percent change (APC) of incidence rate trends, with 95{\%} confidence intervals (95{\%}CI), were computed. The study included 46,857 CRCs diagnosed in subjects aged 40-79 years, of which 2,806 were screendetected. The incidence rates in the North-Centre were higher than in the South and on the Islands. During the study period, screening programmes had been implemented only in the North-Centre and had a significant effect on incidence rates, with an initial sharp increase in incidence, followed by a decrease that started in the 3rd-4th years of screening. These incidence rate trends were exclusively due to modifications in the rates of stage I cases. After screening programmes started, incidence increased in all anatomic sites, particularly in the distal colon. The differential figures introduced by the implementation of screening programmes warrant a continuous surveillance of CRC incidence and mortality trends to monitor the impact of screening at a national level.",
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T1 - Incidence trends of colorectal cancer in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening

AU - Zorzi, Manuel

AU - Mangone, Lucia

AU - Sassatelli, Romano

AU - Baracco, Susanna

AU - Budroni, Mario

AU - Castaing, Marine

AU - Cirilli, Claudia

AU - Cusimano, Rosanna

AU - Fusco, M.

AU - Giacomin, Adriano

AU - Rossi, Paolo Giorgi

AU - Naldoni, Carlo

AU - Pannozzo, Fabio

AU - Piffer, Silvano

AU - Puppo, Antonella

AU - Tisano, Francesco

AU - Zappa, Marco

AU - Azzoni, A.

AU - Baldazzi, P.

AU - Collina, N.

AU - Pandolfi, P.

AU - Petrucci, C.

AU - Gualandi, G.

AU - Sciacchitano, S.

AU - Ieni, A.

AU - Bella, F.

AU - Torrisi, A.

AU - Varvarà, M.

AU - Finarelli, A. C.

AU - De Bianchi, P. Sassoli

AU - Landi, P.

AU - Ferretti, S.

AU - Matarese, V.

AU - De Togni, A.

AU - Palmonari, C.

AU - Caldarella, A.

AU - Crocetti, E.

AU - Grazzini, G.

AU - Manneschi, G.

AU - Mantellini, P.

AU - Serraino, D.

AU - Bidoli, E.

AU - Taborelli, M.

AU - Gini, A.

AU - Virdone, S.

AU - Casella, C.

AU - Celesia, M.

AU - Cogno, R.

AU - Marani, E.

AU - Busco, S.

AU - Bernazza, E.

AU - Curatella, S.

AU - Macci, L.

AU - Rossi, M.

AU - Randi, G.

AU - Frammartino, B.

AU - Bonini, A.

AU - Filippazzi, L.

AU - Giubelli, C.

AU - Corradini, R.

AU - De Girolamo, F.

AU - Valla, K.

AU - Palombino, R.

AU - D'Orsi, M.

AU - Isernia, M.

AU - Fusco, M.

AU - Vitale, F. M.

AU - Adamo, M. S.

AU - Amodio, R.

AU - Brucculeri, A.

AU - Guttadauro, A.

AU - Mazzucco, W.

AU - Sgarzi, P.

AU - Bozzani, F.

AU - Zatelli, M.

AU - Zurlini, C.

AU - Caruana, P.

AU - Borciani, E.

AU - Gatti, G.

AU - Prazzoli, R.

AU - Seghini, P.

AU - Campari, C.

AU - Di Felice, E.

AU - Sacchettini, C.

AU - Cassetti, T.

AU - Falcini, F.

AU - Mancini, S.

AU - Vattiato, R.

AU - Giuliani, O.

AU - Caprara, L.

AU - Cesaraccio, R.

AU - Sechi, O.

AU - Madeddu, A.

AU - Contrino, M. L.

AU - Colanino Ziino, A.

AU - Russo, M.

AU - Fanetti, A. C.

AU - Maspero, S.

AU - Moroni, E.

AU - Cometti, I.

AU - Gentilini, M.

AU - De Pretis, G.

AU - Caciagli, P.

AU - Pertile, R.

AU - Bianconi, F.

AU - Masanotti, G. M.

AU - De Lio, M. C.

AU - Leite, S.

AU - Passamonti, B. U.

AU - Dei Tos, A. P.

AU - Rosano, A.

AU - Monetti, D.

AU - Guzzinati, S.

AU - Tognazzo, S.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - We utilised the IMPATTO study's archives to describe the 2000-2008 colorectal cancer (CRC) incidence rate trends in Italy, once screening programmes based on the faecal immunochemical test were implemented in different areas. Data on CRCs diagnosed in Italy from 2000 to 2008 in subjects aged 40-79 years were collected by 23 cancer registries. Incidence rate trends were evaluated as a whole and by macro-area (North-Centre and South-Islands), presence of a screening programme, sex, ten-year age class, anatomic site, stage at diagnosis, and pattern of diagnosis (screen-detected, non-screen-detected). The annual percent change (APC) of incidence rate trends, with 95% confidence intervals (95%CI), were computed. The study included 46,857 CRCs diagnosed in subjects aged 40-79 years, of which 2,806 were screendetected. The incidence rates in the North-Centre were higher than in the South and on the Islands. During the study period, screening programmes had been implemented only in the North-Centre and had a significant effect on incidence rates, with an initial sharp increase in incidence, followed by a decrease that started in the 3rd-4th years of screening. These incidence rate trends were exclusively due to modifications in the rates of stage I cases. After screening programmes started, incidence increased in all anatomic sites, particularly in the distal colon. The differential figures introduced by the implementation of screening programmes warrant a continuous surveillance of CRC incidence and mortality trends to monitor the impact of screening at a national level.

AB - We utilised the IMPATTO study's archives to describe the 2000-2008 colorectal cancer (CRC) incidence rate trends in Italy, once screening programmes based on the faecal immunochemical test were implemented in different areas. Data on CRCs diagnosed in Italy from 2000 to 2008 in subjects aged 40-79 years were collected by 23 cancer registries. Incidence rate trends were evaluated as a whole and by macro-area (North-Centre and South-Islands), presence of a screening programme, sex, ten-year age class, anatomic site, stage at diagnosis, and pattern of diagnosis (screen-detected, non-screen-detected). The annual percent change (APC) of incidence rate trends, with 95% confidence intervals (95%CI), were computed. The study included 46,857 CRCs diagnosed in subjects aged 40-79 years, of which 2,806 were screendetected. The incidence rates in the North-Centre were higher than in the South and on the Islands. During the study period, screening programmes had been implemented only in the North-Centre and had a significant effect on incidence rates, with an initial sharp increase in incidence, followed by a decrease that started in the 3rd-4th years of screening. These incidence rate trends were exclusively due to modifications in the rates of stage I cases. After screening programmes started, incidence increased in all anatomic sites, particularly in the distal colon. The differential figures introduced by the implementation of screening programmes warrant a continuous surveillance of CRC incidence and mortality trends to monitor the impact of screening at a national level.

KW - Colorectal cancer

KW - Fecal immunochemical test

KW - Incidence rates

KW - Italy

KW - Screening

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UR - http://www.scopus.com/inward/citedby.url?scp=85016104155&partnerID=8YFLogxK

M3 - Review article

C2 - 26405783

AN - SCOPUS:85016104155

VL - 39

SP - 115

EP - 125

JO - Epidemiologia e prevenzione

JF - Epidemiologia e prevenzione

SN - 1120-9763

IS - 3

ER -