Incidental Epstein-Barr virus associated atypical lymphoid proliferation arising in a left atrial myxoma: A case of long survival without any postsurgical treatment and review of the literature

Giovanni Bartoloni, Angela Pucci, Alexandra Giorlandino, Massimiliano Berretta, Carmelo Mignosa, Fabrizio Italia, Antonino Carbone, Vincenzo Canzonieri

Research output: Contribution to journalArticle

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Abstract

We report a case of left atrial cardiac myxoma harbouring an incidental atypical B-cell lymphoid proliferation. Histology disclosed classic myxoma cells embedded in a mucopolysaccharide-rich matrix and a micronodular atypical lymphoid proliferation under the surface of the mass. Myxoma cells were immunoreactive for calretinin, while lymphoid cells expressed B lineage markers (CD 20+, CD79a), without evidence of clonality. Moreover, they were LMP1 positive; EBNA2 negative; KSHV/HHV8 negative; and, by in situ hybridization, EBER/Epstein-Barr virus (EBV) positive and Kappa and Lambda negative. According to the 2008 WHO schemes, the present case shares close similarities either with diffuse large B-cell lymphomas growing in the context of long-standing chronic inflammation or with primary effusion lymphomas, solid variant, both associated with EBV infection. This is the sixth case of incidental atypical lymphoid proliferation discovered in a cardiac myxoma reported so far. The optimal treatment of such lesions remains undefined, but their clinical course is indolent. After an accurate staging workup, without any postsurgical treatment, the patient we observed has been well with no recurrence of the disease at 6 years of follow-up.

Original languageEnglish
JournalCardiovascular Pathology
Volume22
Issue number3
DOIs
Publication statusPublished - May 2013

Fingerprint

Myxoma
Human Herpesvirus 4
Survival
Primary Effusion Lymphoma
Calbindin 2
Human Herpesvirus 8
Epstein-Barr Virus Infections
Lymphoma, Large B-Cell, Diffuse
Therapeutics
Glycosaminoglycans
In Situ Hybridization
Histology
B-Lymphocytes
Cell Proliferation
Lymphocytes
Inflammation
Recurrence

Keywords

  • Cardiac myxoma
  • E.B.virus infection
  • Large cell lymphoma

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

Cite this

Incidental Epstein-Barr virus associated atypical lymphoid proliferation arising in a left atrial myxoma : A case of long survival without any postsurgical treatment and review of the literature. / Bartoloni, Giovanni; Pucci, Angela; Giorlandino, Alexandra; Berretta, Massimiliano; Mignosa, Carmelo; Italia, Fabrizio; Carbone, Antonino; Canzonieri, Vincenzo.

In: Cardiovascular Pathology, Vol. 22, No. 3, 05.2013.

Research output: Contribution to journalArticle

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