Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer

Marina Hodolic, Virginie Huchet, Sona Balogova, Laure Michaud, Khaldoun Kerrou, Valérie Nataf, Marino Cimitan, Jure Fettich, Jean Noël Talbot

Research output: Contribution to journalArticle

Abstract

Background: Positron emission tomography-computed tomography (PET/CT) with 18F-fluorocholine (FCH) is routinely performed in patients with prostate cancer. In this clinical context, foci of FCH uptake in the head or in the neck were considered as incidentalomas, except for those suggestive of multiple bone metastases. Results: In 8 patients the incidental focus corresponded to a benign tumour. The standard of truth was histology in two cases, correlative imaging with MRI in four cases, 99mTc-SestaMIBI scintigraphy, ultrasonography and biochemistry in one case and biochemistry including PTH assay in one case. The final diagnosis of benign tumours consisted in 3 pituitary adenomas, 2 meningiomas, 2 hyperfunctioning parathyroid glands and 1 thyroid adenoma. Malignancy was proven histologically in 2 other patients: 1 papillary carcinoma of the thyroid and 1 cerebellar metastasis. Conclusions: To the best of our knowledge, FCH uptake by pituitary adenomas or hyperfunctioning parathyroid glands has never been described previously. We thus discuss whether there might be a future indication for FCH PET/CT when one such tumour is already known or suspected: to detect a residual or recurrent pituitary adenoma after surgery, to guide surgery or radiotherapy of a meningioma or to localise a hyperfunctioning parathyroid gland. In these potential indications, comparative studies with reference PET tracers or with 99mTc-sestaMIBI in case of hyperparathyroidism could be undertaken.

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalRadiology and Oncology
Volume48
Issue number3
DOIs
Publication statusPublished - Sep 1 2014

Fingerprint

Parathyroid Glands
Prostatic Neoplasms
Pituitary Neoplasms
Neck
Head
Meningioma
Biochemistry
Neoplasms
Neoplasm Metastasis
Technetium Tc 99m Sestamibi
Hyperparathyroidism
Thyroid Neoplasms
Radionuclide Imaging
Ultrasonography
Histology
Radiotherapy
Bone and Bones
fluorocholine
Positron Emission Tomography Computed Tomography

Keywords

  • FCH, PET/CT
  • Hyperparathyroidism
  • Incidentaloma
  • Meningioma
  • Pituitary adenoma
  • Thyroid adenoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Hodolic, M., Huchet, V., Balogova, S., Michaud, L., Kerrou, K., Nataf, V., ... Talbot, J. N. (2014). Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer. Radiology and Oncology, 48(3), 228-234. https://doi.org/10.2478/raon-2013-0075

Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer. / Hodolic, Marina; Huchet, Virginie; Balogova, Sona; Michaud, Laure; Kerrou, Khaldoun; Nataf, Valérie; Cimitan, Marino; Fettich, Jure; Talbot, Jean Noël.

In: Radiology and Oncology, Vol. 48, No. 3, 01.09.2014, p. 228-234.

Research output: Contribution to journalArticle

Hodolic, M, Huchet, V, Balogova, S, Michaud, L, Kerrou, K, Nataf, V, Cimitan, M, Fettich, J & Talbot, JN 2014, 'Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer', Radiology and Oncology, vol. 48, no. 3, pp. 228-234. https://doi.org/10.2478/raon-2013-0075
Hodolic, Marina ; Huchet, Virginie ; Balogova, Sona ; Michaud, Laure ; Kerrou, Khaldoun ; Nataf, Valérie ; Cimitan, Marino ; Fettich, Jure ; Talbot, Jean Noël. / Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer. In: Radiology and Oncology. 2014 ; Vol. 48, No. 3. pp. 228-234.
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AU - Huchet, Virginie

AU - Balogova, Sona

AU - Michaud, Laure

AU - Kerrou, Khaldoun

AU - Nataf, Valérie

AU - Cimitan, Marino

AU - Fettich, Jure

AU - Talbot, Jean Noël

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AB - Background: Positron emission tomography-computed tomography (PET/CT) with 18F-fluorocholine (FCH) is routinely performed in patients with prostate cancer. In this clinical context, foci of FCH uptake in the head or in the neck were considered as incidentalomas, except for those suggestive of multiple bone metastases. Results: In 8 patients the incidental focus corresponded to a benign tumour. The standard of truth was histology in two cases, correlative imaging with MRI in four cases, 99mTc-SestaMIBI scintigraphy, ultrasonography and biochemistry in one case and biochemistry including PTH assay in one case. The final diagnosis of benign tumours consisted in 3 pituitary adenomas, 2 meningiomas, 2 hyperfunctioning parathyroid glands and 1 thyroid adenoma. Malignancy was proven histologically in 2 other patients: 1 papillary carcinoma of the thyroid and 1 cerebellar metastasis. Conclusions: To the best of our knowledge, FCH uptake by pituitary adenomas or hyperfunctioning parathyroid glands has never been described previously. We thus discuss whether there might be a future indication for FCH PET/CT when one such tumour is already known or suspected: to detect a residual or recurrent pituitary adenoma after surgery, to guide surgery or radiotherapy of a meningioma or to localise a hyperfunctioning parathyroid gland. In these potential indications, comparative studies with reference PET tracers or with 99mTc-sestaMIBI in case of hyperparathyroidism could be undertaken.

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