Incision of AP sites in lung cancer patients: A pilot study

Ottavio Rossi, Rosangela Filiberti, Monica Neri, Stefano Biggi, Livia Satragno, Riccardo Puntoni, Guido Frosina

Research output: Contribution to journalArticle

Abstract

DNA base excision repair (BER) removes frequent DNA lesions of either endogenous or exogenous origin. Some indications point to BER defects in lung cancer patients. We have investigated the ability of ten lung cancer patients to repair natural AP sites, the most frequent genetic lesion, using an in vitro assay in which peripheral blood lymphocytes (PBL) extracts incise randomly depurinated plasmid DNA. The median value of repair activity in patients was lower than that of matched controls but the difference did not reach significance. Unlike other BER enzymatic steps, marked defects in incision of AP sites may not be associated with lung carcinogenesis.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalTeratogenesis Carcinogenesis and Mutagenesis
Volume22
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • AP sites
  • Cancer susceptibility
  • DNA repair
  • Endogenous damage
  • Lung cancer

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis
  • Genetics(clinical)
  • Oncology
  • Toxicology

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