Inclusion of serum bile acids in Child-Turcotte-Pugh's score can improve grading assessment of alcoholic cirrhosis

R. Testa, P. Bindi, F. Dagnino, A. Grasso, E. Bardellini, G. Celle

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate whether the inclusion of serum bile acids as a parameter improves functional assessment of the Child-Turcotte-Pugh's (CTP) classification. Design: Serum bile acid levels and CTP scores were tested in relation to hepatic clearance and extraction ratio of indocyanin green and hepatic clearance of chenodeoxycholic acid. Methods: In 50 patients with alcoholic cirrhosis serum bile acids levels and CTP score were assessed using both indocyanin green (0.25 mg/kg i.v.) and chenodeoxycholic acid (250 mg oral capsule) kinetics Results: Inclusion of serum bile acids in the CTP classification changed the severity grading of 15% of cirrhosis patients, and improved the relationship with indocyanin green hepatic clearance and extraction ratio. Conclusion: Inclusion of serum bile acids in the CTP score enables a more quantitative clinical evaluation of cirrhosis to be made.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume4
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Gastroenterology

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