Incomplete coverage of candidate genes: A poorly considered bias

Antonio Drago, Diana De Ronchi, Alessandro Serretti

Research output: Contribution to journalArticlepeer-review


Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons for this inconsistency, among them a well known but poorly considered issue is gene coverage. The aim of the present paper is to focus on this well known and defectively deemed bias, especially when a candidate gene approach is chosen. The rational and the technical feasibility of this proposal are discussed as well as a survey of current investigations. The known consistent methodology to fix this bias is also discussed.

Original languageEnglish
Pages (from-to)476-483
Number of pages8
JournalCurrent Genomics
Issue number7
Publication statusPublished - Nov 2007


  • Association studies
  • Candidate genes
  • Methodology
  • Psychiatry genetics

ASJC Scopus subject areas

  • Genetics


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