Incorporation and washout of n-3 polyunsaturated fatty acids after diet supplementation in clinical studies

Serge Masson, Roberto Latini, Mariateresa Tacconi, Roberto Bernasconi

Research output: Contribution to journalArticle

Abstract

Current evidence suggests that at least part of the cardioprotective benefits of consumption of long-chain n-3 polyunsaturated fatty acids (PUFAs) relates to their incorporation into the phospholipids of cardiac cell membranes. Dietary supplementation with purified extracts of n-3 PUFAs derived from fish oil rapidly alters the composition of fatty acids in blood cell membranes and in other tissues. The present review summarises the time-course and dose-dependent incorporation and washout of n-3 PUFAs in the clinical setting and discusses the implications of these pharmacokinetic data in terms of biological effects.

Original languageEnglish
JournalJournal of Cardiovascular Medicine
Volume8
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Fish oils
  • n-3 polyunsaturated fatty acids
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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