Increase in dopamine content of the rat median eminence after long-term ovariectomy and its reversal by estrogen replacement

G. A. Gudelsky, L. Annunziato, K. E. Moore

Research output: Contribution to journalArticle

Abstract

The norepinephrine (NE) and dopamine (DA) concentrations of the median eminence and the remaining hypothalamus of female rats were assayed using a sensitive radioenzymatic method. There were no changes in the catecholamine concentrations of either brain region when measured in the mornings of the different days of the estrous cycle. Four to 5 weeks after ovariectomy there was a marked increase in the DA but not the NE content of the median eminence, and the daily administration of estradiol benzoate for 7 days prior to sacrifice reversed the ovariectomy-induced increase in DA. Ovariectomy did not alter catecholamine concentrations in the remaining hypothalamus.

Original languageEnglish
Pages (from-to)1894-1897
Number of pages4
JournalEndocrinology
Volume101
Issue number6
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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