Abstract
The anorectic agent, d-fenfluramine, maximally increased the acetylcholine content in the striatum by 50% at doses of 5-10 mg/kg. The action of the drug was completely prevented by treatments designed to interfere with serotonergic transmission (e.g., combined electrolytic lesion of the nucleus raphe medianus and dorsalis; pretreatments with methergoline, parachlorophenylalanine or fluoxetine). By contrast, interference with dopaminergic transmission (e.g., lesion of the nigrostriatal dopaminergic tract with 6-OHDA; pre-treatment with penfluridol) did not impede the action of d-fenfluramine. The administration of d-fenfluramine to animals given a supramaximal dose of apomorphine, 1.5 mg/kg, produced a summated increase in striatal acetylcholine. The data are consistent with the hypothesis that there may exist in the striatum different populations of cholinergic interneurons regulated by serotonin and dopamine, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 1975-1981 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 25 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Dec 3 1979 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Increase in rat striatal acetylcholine content by d-fenfluramine, a serotonin releaser. / Consolo, Silvana; Ladinsky, Herbert; Tirelli, Amedea Silvia; Crunelli, Vincenzo; Samanin, Rosario; Garattini, Silvio.
In: Life Sciences, Vol. 25, No. 23, 03.12.1979, p. 1975-1981.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increase in rat striatal acetylcholine content by d-fenfluramine, a serotonin releaser
AU - Consolo, Silvana
AU - Ladinsky, Herbert
AU - Tirelli, Amedea Silvia
AU - Crunelli, Vincenzo
AU - Samanin, Rosario
AU - Garattini, Silvio
PY - 1979/12/3
Y1 - 1979/12/3
N2 - The anorectic agent, d-fenfluramine, maximally increased the acetylcholine content in the striatum by 50% at doses of 5-10 mg/kg. The action of the drug was completely prevented by treatments designed to interfere with serotonergic transmission (e.g., combined electrolytic lesion of the nucleus raphe medianus and dorsalis; pretreatments with methergoline, parachlorophenylalanine or fluoxetine). By contrast, interference with dopaminergic transmission (e.g., lesion of the nigrostriatal dopaminergic tract with 6-OHDA; pre-treatment with penfluridol) did not impede the action of d-fenfluramine. The administration of d-fenfluramine to animals given a supramaximal dose of apomorphine, 1.5 mg/kg, produced a summated increase in striatal acetylcholine. The data are consistent with the hypothesis that there may exist in the striatum different populations of cholinergic interneurons regulated by serotonin and dopamine, respectively.
AB - The anorectic agent, d-fenfluramine, maximally increased the acetylcholine content in the striatum by 50% at doses of 5-10 mg/kg. The action of the drug was completely prevented by treatments designed to interfere with serotonergic transmission (e.g., combined electrolytic lesion of the nucleus raphe medianus and dorsalis; pretreatments with methergoline, parachlorophenylalanine or fluoxetine). By contrast, interference with dopaminergic transmission (e.g., lesion of the nigrostriatal dopaminergic tract with 6-OHDA; pre-treatment with penfluridol) did not impede the action of d-fenfluramine. The administration of d-fenfluramine to animals given a supramaximal dose of apomorphine, 1.5 mg/kg, produced a summated increase in striatal acetylcholine. The data are consistent with the hypothesis that there may exist in the striatum different populations of cholinergic interneurons regulated by serotonin and dopamine, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0018580102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018580102&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(79)90601-5
DO - 10.1016/0024-3205(79)90601-5
M3 - Article
C2 - 231171
AN - SCOPUS:0018580102
VL - 25
SP - 1975
EP - 1981
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 23
ER -