Increase in rat striatal acetylcholine content by d-fenfluramine, a serotonin releaser

Silvana Consolo, Herbert Ladinsky, Amedea Silvia Tirelli, Vincenzo Crunelli, Rosario Samanin, Silvio Garattini

Research output: Contribution to journalArticle

Abstract

The anorectic agent, d-fenfluramine, maximally increased the acetylcholine content in the striatum by 50% at doses of 5-10 mg/kg. The action of the drug was completely prevented by treatments designed to interfere with serotonergic transmission (e.g., combined electrolytic lesion of the nucleus raphe medianus and dorsalis; pretreatments with methergoline, parachlorophenylalanine or fluoxetine). By contrast, interference with dopaminergic transmission (e.g., lesion of the nigrostriatal dopaminergic tract with 6-OHDA; pre-treatment with penfluridol) did not impede the action of d-fenfluramine. The administration of d-fenfluramine to animals given a supramaximal dose of apomorphine, 1.5 mg/kg, produced a summated increase in striatal acetylcholine. The data are consistent with the hypothesis that there may exist in the striatum different populations of cholinergic interneurons regulated by serotonin and dopamine, respectively.

Original languageEnglish
Pages (from-to)1975-1981
Number of pages7
JournalLife Sciences
Volume25
Issue number23
DOIs
Publication statusPublished - Dec 3 1979

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Fenfluramine
Corpus Striatum
Acetylcholine
Rats
Serotonin
Penfluridol
Metergoline
Appetite Depressants
Apomorphine
Fluoxetine
Oxidopamine
Interneurons
Cholinergic Agents
Dopamine
Animals
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Pharmacology

Cite this

Increase in rat striatal acetylcholine content by d-fenfluramine, a serotonin releaser. / Consolo, Silvana; Ladinsky, Herbert; Tirelli, Amedea Silvia; Crunelli, Vincenzo; Samanin, Rosario; Garattini, Silvio.

In: Life Sciences, Vol. 25, No. 23, 03.12.1979, p. 1975-1981.

Research output: Contribution to journalArticle

Consolo, Silvana ; Ladinsky, Herbert ; Tirelli, Amedea Silvia ; Crunelli, Vincenzo ; Samanin, Rosario ; Garattini, Silvio. / Increase in rat striatal acetylcholine content by d-fenfluramine, a serotonin releaser. In: Life Sciences. 1979 ; Vol. 25, No. 23. pp. 1975-1981.
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