Increase of aldosterone secretion following acute haloperidol administration: Possible clinical implications

P. Liberini, E. Nisoli, C. Missale, C. Turrina, G. B. Frisoni, R. Caruso, P. F. Spano

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was designed to investigate the effect of haloperidol on plasma corticosteroid levels in a small sample of unmedicated psychiatric patients requiring acute care. Seven young male normotensive subjects in metabolic balance received a single dose of haloperidol (2 mg i.v.). Blood samples were collected for the radioimmunoassay of plasma renin activity, cortisol and aldosterone concentration at baseline and 3, 6, 12 and 24 h after injection. In five out of seven patients a significant, transient elevation of plasma aldosterone level was observed within 12 h from administration. In contrast, plasma renin activity and cortisol concentration were unchanged. Possible clinical implications of the neuroleptic-associated aldosterone elevation are discussed.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalInternational Clinical Psychopharmacology
Volume11
Issue number1
DOIs
Publication statusPublished - 1996

Keywords

  • aldosterone
  • cortisol
  • dopamine receptors
  • haloperidol
  • renin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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