Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants

Jan Knol, Günther Boehm, Maura Lidestri, Franco Negretti, Jürgen Jelinek, Massimo Agosti, Bernd Stahl, Antonio Marini, Fabio Mosca

Research output: Contribution to journalArticlepeer-review

Abstract

In a previous study on formula-fed preterm infants, we were able to demonstrate that dietary oligosaccharides (a mixture of 90% galacto- oligosaccharides and 10% fructo-oligosaccharides in a concentration of 1 g/dl) stimulate the growth of faecal bifidobacteria. In the present explorative analysis of this study, we focus on the effect of the dominance of bifidobacteria on the presence of clinically relevant pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Pseudomonas aeruginosa, Enterobacter, Klebsiella, Proteus, Streptococcus group B, Clostridium difficile, Bacillus subtilis and Acinetobacter). Conclusion: The data demonstrate that stimulation of bifidobacteria by prebiotic oligosaccharides reduces the presence of clinically relevant pathogens in the faecal flora, indicating that prebiotic substances might have the capacity to protect against enteral infections.

Original languageEnglish
Pages (from-to)31-33
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics, Supplement
Volume94
Issue number449
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Bifidobacteria
  • Faecal flora
  • Fructo-oligosaccharides
  • Galacto-oligosaccharides
  • Pathogens

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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