Increase of mouse resistance to Candida albicans infection by thymosin α1

F. Bistoni, P. Marconi, L. Frati, E. Bonmassar, E. Garaci

Research output: Contribution to journalArticle

Abstract

Studies were carried out to assess the ability of thymosin α1 to prolong the survival of mice challenged with Candida albicans. Two- to four-month-old mice were treated with graded doses of thymosin α1 before, after, or before and after intravenous challenge with C. albicans. Significant resistance to lethal infection was afforded by 100 μg of thymosin α1 per kg given before or before and after challenge, whereas no protection was found in mice treated with thymosin α1 administered at any dose level after inoculation. Pretreatment with thymosin α1 also prevented the increased susceptibility to C. albicans infection of mice pretreated with cyclophosphamide on day -6. The results showed that thymosin α1 was capable of protecting untreated or cyclophosphamide-pretreated mice from C. albicans infection at an optimal dose and schedule of administration.

Original languageEnglish
Pages (from-to)609-614
Number of pages6
JournalInfection and Immunity
Volume36
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Increase of mouse resistance to Candida albicans infection by thymosin α1'. Together they form a unique fingerprint.

  • Cite this

    Bistoni, F., Marconi, P., Frati, L., Bonmassar, E., & Garaci, E. (1982). Increase of mouse resistance to Candida albicans infection by thymosin α1 . Infection and Immunity, 36(2), 609-614.