Increase of suicide and accidental death after hematopoietic stem cell transplantation: A cohort study on behalf of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

André Tichelli, Myriam Labopin, Alicia Rovõ, Manuela Badoglio, Mutlu Arat, Maria Teresa Van Lint, Anita Lawitschka, Carl Philipp Schwarze, Jakob Passweg, Gérard Socié

Research output: Contribution to journalArticle

Abstract

BACKGROUND Relapse and transplant-related complications are leading causes of mortality after hematopoietic stem cell transplantation (HSCT). Suicides and accidents have not been studied in these patients. This study sought to determine whether there is an excess of suicide and accidental deaths after HSCT, and to determine risk factors. METHODS The incidence of suicidal and accidental death in patients after undergoing HSCT, standardized mortality ratio (SMR), and absolute excess risk (AER) of suicide and accidental deaths was determined, compared with the general European population. A case-control analysis was done to define factors associated with suicide and accidental deaths. Data were derived from the European Group for Blood and Marrow Transplantation Registry, including 294,922 patients who underwent autologous or allogeneic HSCT from 1980 to 2009. RESULTS The 10-year cumulative incidence of suicide and accidental deaths was 101.8 and 55.6 per 100,000 patients, respectively. SMR and AER of suicide after HSCT were 2.12 (P

Original languageEnglish
Pages (from-to)2012-2021
Number of pages10
JournalCancer
Volume119
Issue number11
DOIs
Publication statusPublished - Jun 1 2013

Keywords

  • accidents
  • hematopoietic stem cell transplantation
  • late effects
  • long-term
  • suicides
  • survivorship

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Increase of suicide and accidental death after hematopoietic stem cell transplantation: A cohort study on behalf of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation (EBMT)'. Together they form a unique fingerprint.

  • Cite this