TY - JOUR
T1 - Increase of theta/Gamma and Alpha3/Alpha2 ratio is associated with amygdalo-hippocampal complex atrophy
AU - Moretti, Davide Vito
AU - Pievani, Michela
AU - Fracassi, Claudia
AU - Binetti, Giuliano
AU - Rosini, Sandra
AU - Geroldi, Cristina
AU - Zanetti, Orazio
AU - Rossini, Paolo M.
AU - Frisoni, Giovanni B.
PY - 2009
Y1 - 2009
N2 - We evaluated the association between amygdalo-hippocampal complex (AHC) atrophy and two electroencephalography (EEG) markers of cognitive decline: increase of theta/gamma and increase of alpha3/alpha2 relative power ratio. Seventy-nine subjects with mild cognitive impairment (MCI) underwent EEG recording and magnetic resonance imaging scan. Based on the tertiles values of decreasing AHC volume, three groups of AHC growing atrophy were obtained. The groups were characterized by the performance to cognitive tests and theta/gamma and alpha3/alpha2 relative power ratio. AHC atrophy is associated with memory deficits as well as with increase of theta/gamma and alpha3/alpha2 ratio. Moreover, when the amygdalar and hippocampal volume are separately considered within AHC, the increase of theta/gamma ratio is best associated with amygdalar atrophy whereas alpha3/alpha2 ratio is best associated with hippocampal atrophy. AHC atrophy is associated with memory deficits and EEG markers of cognitive decline. So far, these EEG markers could have a prospective value in differential diagnosis between patients with MCI who develop dementia and those who do not as well as between MCI patients who will develop Alzheimer's disease and those who develop non-Alzheimer's disease dementias. The alterations of the functional connections, inducing global network pathological changes, in the whole AHC could better explain MCI state.
AB - We evaluated the association between amygdalo-hippocampal complex (AHC) atrophy and two electroencephalography (EEG) markers of cognitive decline: increase of theta/gamma and increase of alpha3/alpha2 relative power ratio. Seventy-nine subjects with mild cognitive impairment (MCI) underwent EEG recording and magnetic resonance imaging scan. Based on the tertiles values of decreasing AHC volume, three groups of AHC growing atrophy were obtained. The groups were characterized by the performance to cognitive tests and theta/gamma and alpha3/alpha2 relative power ratio. AHC atrophy is associated with memory deficits as well as with increase of theta/gamma and alpha3/alpha2 ratio. Moreover, when the amygdalar and hippocampal volume are separately considered within AHC, the increase of theta/gamma ratio is best associated with amygdalar atrophy whereas alpha3/alpha2 ratio is best associated with hippocampal atrophy. AHC atrophy is associated with memory deficits and EEG markers of cognitive decline. So far, these EEG markers could have a prospective value in differential diagnosis between patients with MCI who develop dementia and those who do not as well as between MCI patients who will develop Alzheimer's disease and those who develop non-Alzheimer's disease dementias. The alterations of the functional connections, inducing global network pathological changes, in the whole AHC could better explain MCI state.
KW - Amygdalo-hippocampal complex
KW - Cognitive tests
KW - Electroencephalography
KW - Gamma rhythm
KW - Mild cognitive impairment
KW - Theta rhythm
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UR - http://www.scopus.com/inward/citedby.url?scp=67849119974&partnerID=8YFLogxK
U2 - 10.3233/JAD-2009-1059
DO - 10.3233/JAD-2009-1059
M3 - Article
C2 - 19363263
AN - SCOPUS:67849119974
VL - 17
SP - 349
EP - 357
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -