Increased ability of apomorphine to reduce concentrations of prolactin in rats treated chronically with α-methyltyrosine

Lucio Annunziato, Kenneth E. Moore

Research output: Contribution to journalArticle

Abstract

Serum concentrations of prolactin were significantly increased in rats for up to 9 hours after a single i.p. injection of α-methyltyrosine (50 mg/kg); apomorphine caused a dose-dependent reduction of the elevated prolactin concentrations. Doses of apomorphine required to reduce serum prolactin concentrations.were lower in animals previously injected with α-methyltyrosine three times a day for 10 days than in animals which received a single injection of α-methyltyrosine. These results suggest that chronic disruption of the normal release of dopamine from tuberoinfundibular neurons leads to the development of increased sensitivity of dopamine receptors involved with the inhibition of prolactin release from the anterior pituitary.

Original languageEnglish
Pages (from-to)1845-1849
Number of pages5
JournalLife Sciences
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 15 1977

ASJC Scopus subject areas

  • Pharmacology

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