Increased acetylcholine sensitivity in Duchenne muscular dystrophy myotubes

G. Meola, E. Mancinelli, L. Geremia, G. Scarlato

Research output: Contribution to journalArticlepeer-review

Abstract

Monolayer cultures were established from explants of muscle obtained from 6 patients with Duchenne muscular dystrophy (DMD) and 9 controls. Electrophysiological studies were made after 3-4 weeks in vitro, when many myotubes had formed. An intracellular electrode was used to record cell membrane potential, and acetylcholine was applied by ionophoresis. The myotubes grown from Duchenne muscle showed greater acetylcholine sensitivity than controls.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalItalian Journal of Neurological Sciences
Volume12
Issue number2
DOIs
Publication statusPublished - Apr 1991

Keywords

  • ACh ionophoresis
  • ACh sensitivity
  • Duchenne muscular dystrophy
  • human muscle culture
  • human myotubes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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