Increased activation effects of succinylcholine in neurosurgical patients

F. Fiacchino, C. Giorgi, C. Ferrazza, M. Montolivo, M. Bricchi, L. Ferrario, F. Pluchino, V. Borroni

Research output: Contribution to journalArticle

Abstract

Succinylcholine, a depolarizing muscle relaxant with both activating and desensitizing effects, is used to facilitate endotracheal intubation. The activating effects were found to be above-normal on induction of anesthesia in 7 neurosurgical patients: generalized muscle spasm in 1 myotonic patient, contractures or prolonged contractions in "anatomically" denervated muscles (1 patient), in "functionally" denervated muscles (1 patient) and in "centrally" denervated muscles (4 patients). One of these four presented hyperkalemia and cardiocirculatory collapse. It is important to differentiate these anomalous responses to succinylcholine from those occurring as early signs of rhabdomyolysis or malignant hyperthermia.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalItalian Journal of Neurological Sciences
Volume4
Issue number1
DOIs
Publication statusPublished - Apr 1983

Keywords

  • decentralization
  • denervation
  • succinylcholine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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    Fiacchino, F., Giorgi, C., Ferrazza, C., Montolivo, M., Bricchi, M., Ferrario, L., Pluchino, F., & Borroni, V. (1983). Increased activation effects of succinylcholine in neurosurgical patients. Italian Journal of Neurological Sciences, 4(1), 27-33. https://doi.org/10.1007/BF02043434