Increased airway smooth muscle in preschool wheezers who have asthma at school age

Ruth O'Reilly, Nicola Ullmann, Samantha Irving, Cara J. Bossley, Samatha Sonnappa, Jie Zhu, Timothy Oates, Winston Banya, Peter K. Jeffery, Andrew Bush, Sejal Saglani

Research output: Contribution to journalArticle

Abstract

Background: Increased airway smooth muscle (ASM) is a feature of established asthma in schoolchildren, but nothing is known about ASM in preschool wheezers. Objective: We sought to determine endobronchial biopsy specimen ASM area fraction in preschool wheezers and its association with asthma at school age. Methods: ASM area, reticular basement membrane thickness, and mucosal eosinophil and ASM mast cell values were quantified in endobronchial biopsy specimens previously obtained from preschool children undergoing clinically indicated bronchoscopy: severe recurrent wheezers (n = 47; median age, 26 months) and nonwheezing control subjects (n = 21; median age, 15 months). Children were followed up, and asthma status was established at age 6 to 11 years. Preschool airway pathology was examined in relation to asthma at school age. Results: Forty-two (62%) of 68 children had 1 or more evaluable biopsy specimens for ASM. At school age, 51 of 68 children were followed up, and 15 (40%) of 37 preschool wheezers had asthma. Children who had asthma and an evaluable biopsy specimen had increased preschool ASM area fraction (n = 8; median age, 8.2 years [range, 6-10.4 years]; median ASM, 0.12 [range, 0.08-0.16]) compared with that seen in children without asthma (n = 24; median age, 7.3 years [range, 5.9-11 years]; median ASM, 0.07 [range, 0.02-0.23]; P =.007). However, preschool reticular basement membrane thickness and mucosal eosinophil or ASM mast cell values were not different between those who did or did not have asthma at school age. Conclusion: Increased preschool ASM is associated with those children who have asthma at school age. Thus a focus on early changes in ASM might be important in understanding the subsequent development of childhood asthma.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Volume131
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Smooth Muscle
Asthma
Biopsy
Eosinophils
Basement Membrane
Mast Cells
Smooth Muscle Myocytes
Bronchoscopy
Preschool Children
Pathology

Keywords

  • airway smooth muscle
  • asthma
  • pathology
  • pediatric
  • Preschool wheeze

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Increased airway smooth muscle in preschool wheezers who have asthma at school age. / O'Reilly, Ruth; Ullmann, Nicola; Irving, Samantha; Bossley, Cara J.; Sonnappa, Samatha; Zhu, Jie; Oates, Timothy; Banya, Winston; Jeffery, Peter K.; Bush, Andrew; Saglani, Sejal.

In: Journal of Allergy and Clinical Immunology, Vol. 131, No. 4, 04.2013.

Research output: Contribution to journalArticle

O'Reilly, R, Ullmann, N, Irving, S, Bossley, CJ, Sonnappa, S, Zhu, J, Oates, T, Banya, W, Jeffery, PK, Bush, A & Saglani, S 2013, 'Increased airway smooth muscle in preschool wheezers who have asthma at school age', Journal of Allergy and Clinical Immunology, vol. 131, no. 4. https://doi.org/10.1016/j.jaci.2012.08.044
O'Reilly, Ruth ; Ullmann, Nicola ; Irving, Samantha ; Bossley, Cara J. ; Sonnappa, Samatha ; Zhu, Jie ; Oates, Timothy ; Banya, Winston ; Jeffery, Peter K. ; Bush, Andrew ; Saglani, Sejal. / Increased airway smooth muscle in preschool wheezers who have asthma at school age. In: Journal of Allergy and Clinical Immunology. 2013 ; Vol. 131, No. 4.
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abstract = "Background: Increased airway smooth muscle (ASM) is a feature of established asthma in schoolchildren, but nothing is known about ASM in preschool wheezers. Objective: We sought to determine endobronchial biopsy specimen ASM area fraction in preschool wheezers and its association with asthma at school age. Methods: ASM area, reticular basement membrane thickness, and mucosal eosinophil and ASM mast cell values were quantified in endobronchial biopsy specimens previously obtained from preschool children undergoing clinically indicated bronchoscopy: severe recurrent wheezers (n = 47; median age, 26 months) and nonwheezing control subjects (n = 21; median age, 15 months). Children were followed up, and asthma status was established at age 6 to 11 years. Preschool airway pathology was examined in relation to asthma at school age. Results: Forty-two (62{\%}) of 68 children had 1 or more evaluable biopsy specimens for ASM. At school age, 51 of 68 children were followed up, and 15 (40{\%}) of 37 preschool wheezers had asthma. Children who had asthma and an evaluable biopsy specimen had increased preschool ASM area fraction (n = 8; median age, 8.2 years [range, 6-10.4 years]; median ASM, 0.12 [range, 0.08-0.16]) compared with that seen in children without asthma (n = 24; median age, 7.3 years [range, 5.9-11 years]; median ASM, 0.07 [range, 0.02-0.23]; P =.007). However, preschool reticular basement membrane thickness and mucosal eosinophil or ASM mast cell values were not different between those who did or did not have asthma at school age. Conclusion: Increased preschool ASM is associated with those children who have asthma at school age. Thus a focus on early changes in ASM might be important in understanding the subsequent development of childhood asthma.",
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AU - Zhu, Jie

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