Increased alpha2-macroglobulin in diabetes: A hyperglycemia related phenomenon associated with reduced antithrombin III activity

Antonio Ceriello, Dario Giugliano, Antonio Quatraro, Aldo Stante, Patrizia Dello Russo, Roberto Torella

Research output: Contribution to journalArticlepeer-review


Increased α2-macroglobulin (α2M) activity and concentration, and decreased antithrombin III (ATIII) plasma concentration are reported in diabetic subjects. In diabetes an inverse correlation between ATIII activity and blood glucose, HbA1. α2M activity and α2M concentration, and a direct correlation between both α2M concentration with blood glucose and HbA1 are found. Moreover, a direct correlation between α2M activity and α2M concentration fails. In both diabetic and normal subjects induced hyperglycemia increases α2M activity and α2M concentration reduces ATIII activity, while ATIII concentration is not affected. These data which show that hyperglycemia may increase α2M molecule levels while altering only the biological function of ATIII, provide evidence that hyperglycemia may decrease, directly, the biological function of some proteins and may condition the levels of some risk factors for the development of diabetic complications such as α2M.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalActa Diabetologica Latina
Issue number2
Publication statusPublished - Jun 1989


  • αM concentration
  • Alpha-macroglobulin (αM) activity
  • Antithrombin III (ATIII) activity
  • ATIII concentration
  • Hyperglycemia
  • Non-insulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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