Increased aortic stiffness in adults with chronic indeterminate Chagas disease

Filippo Valbusa, Andrea Angheben, Alessandro Mantovani, Verena Zerbato, Andrea Chiampan, Stefano Bonapace, Paola Rodari, Davide Agnoletti, Guido Arcaro, Cristiano Fava, Zeno Bisoffi, Giovanni Targher

Research output: Contribution to journalArticle

Abstract

An ever-increasing number of patients with chronic indeterminate Chagas disease are diagnosed with early vascular and cardiac abnormalities, as cardiovascular imaging becomes more sensitive. However, the currently available information on aortic stiffness (a prognostic marker for adverse cardiovascular outcomes) in these patients is scarce. In this study, we consecutively recruited 21 asymptomatic Bolivian adult patients with chronic indeterminate Chagas disease and 14 Bolivian adults, who were seronegative for Trypanosoma cruzi infection. No participants had a prior history of heart disease, hypertension, diabetes, chronic kidney disease or atrial fibrillation. Carotid-femoral pulse wave velocity (cf-PWV), carotid-radial PWV (cr-PWV), carotid intima-media thickness and conventional echocardiographic measurements were recorded in all participants. Patients with chronic indeterminate Chagas disease had significantly higher cf-PWV (7.9±1.3 vs. 6.4±1.1 m/s, p = 0.003) and greater HOMA-estimated insulin resistance than subjects without Chagas disease. The two groups did not significantly differ in terms of age, sex, smoking, adiposity measures, blood pressure, plasma lipids, fasting glucose levels as well as cr-PWV, carotid intima-media thickness measurements, left ventricular mass and function. Presence of chronic indeterminate Chagas disease was significantly associated with increasing cf-PWV values (β coefficient: 1.31, 95% coefficient interval 0.44 to 2.18, p = 0.005), even after adjustment for age, sex, heart rate, systolic blood pressure and insulin resistance. In conclusion, asymptomatic Bolivian adult patients with chronic indeterminate Chagas disease have an early and marked increase in aortic stiffness, as measured by cf-PWV, when compared to Bolivian adults who were seronegative for Trypanosoma cruzi infection.

Original languageEnglish
Article numbere0220689
JournalPLoS One
Volume14
Issue number8
DOIs
Publication statusPublished - Jan 1 2019

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Vascular Stiffness
Chagas disease
Chagas Disease
Pulse Wave Analysis
Stiffness
thighs
Thigh
Carotid Intima-Media Thickness
Trypanosoma cruzi
Blood Pressure
insulin resistance
Insulin Resistance
Blood pressure
Cardiovascular Abnormalities
gender
Adiposity
heart diseases
systolic blood pressure
adiposity
Insulin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Valbusa, F., Angheben, A., Mantovani, A., Zerbato, V., Chiampan, A., Bonapace, S., ... Targher, G. (2019). Increased aortic stiffness in adults with chronic indeterminate Chagas disease. PLoS One, 14(8), [e0220689]. https://doi.org/10.1371/journal.pone.0220689

Increased aortic stiffness in adults with chronic indeterminate Chagas disease. / Valbusa, Filippo; Angheben, Andrea; Mantovani, Alessandro; Zerbato, Verena; Chiampan, Andrea; Bonapace, Stefano; Rodari, Paola; Agnoletti, Davide; Arcaro, Guido; Fava, Cristiano; Bisoffi, Zeno; Targher, Giovanni.

In: PLoS One, Vol. 14, No. 8, e0220689, 01.01.2019.

Research output: Contribution to journalArticle

Valbusa, F, Angheben, A, Mantovani, A, Zerbato, V, Chiampan, A, Bonapace, S, Rodari, P, Agnoletti, D, Arcaro, G, Fava, C, Bisoffi, Z & Targher, G 2019, 'Increased aortic stiffness in adults with chronic indeterminate Chagas disease', PLoS One, vol. 14, no. 8, e0220689. https://doi.org/10.1371/journal.pone.0220689
Valbusa F, Angheben A, Mantovani A, Zerbato V, Chiampan A, Bonapace S et al. Increased aortic stiffness in adults with chronic indeterminate Chagas disease. PLoS One. 2019 Jan 1;14(8). e0220689. https://doi.org/10.1371/journal.pone.0220689
Valbusa, Filippo ; Angheben, Andrea ; Mantovani, Alessandro ; Zerbato, Verena ; Chiampan, Andrea ; Bonapace, Stefano ; Rodari, Paola ; Agnoletti, Davide ; Arcaro, Guido ; Fava, Cristiano ; Bisoffi, Zeno ; Targher, Giovanni. / Increased aortic stiffness in adults with chronic indeterminate Chagas disease. In: PLoS One. 2019 ; Vol. 14, No. 8.
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