Increased arterial stiffness in normoglycemic normotensive offspring of type 2 diabetic parents

Cristina Giannattasio, Monica Failla, Anna Capra, Elisabetta Scanziani, Maria Amigoni, Lucia Boffi, Christine Whistock, Pierluigi Gamba, Felice Paleari, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetes is associated with a reduction of arterial distensibility. Limited information exists regarding whether or how early this appears in the course of the disease. We studied 54 normoglycemic, normotensive, healthy offspring of 2 parents with type 2 diabetes mellitus and 55 age- and sex-matched healthy control subjects. Carotid diastolic diameter and systodiastolic change were measured by echo tracking (Wall Track System) and wall thickness by echocolor Doppler (Sonos 5500, Philips). Pulse pressure was measured by a semiautomatic device positioned on the brachial artery and arterial distensibility calculated by Reneman formula. Blood pressure, blood glucose, glycohemoglobin, and insulin sensitivity (homeostasis model assessment index) were normal or only slightly elevated and by and large similar in the 2 groups. Compared with control subjects, offspring of diabetic parents showed similar carotid diameters at diastole and a reduced increase in carotid diameter at systole (-16%), a reduced carotid artery distensibility (-30%), and an increased pulse pressure (+21.8%), all differences being statistically significant (P

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalHypertension
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Arterial distensibility
  • Atherosclerosis
  • Blood pressure
  • Diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine

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