Increased basal nitric oxide plasma concentrations in migraine

D. D'Amico, A. Ferraris, A. Catania, A. Carlin, M. Leone, A. Attanasio, G. Bussone

Research output: Contribution to journalArticle

Abstract

The L-arginine-NO pathway is known to give rise to several effects that could be involved in the pathogenesis of migraine (M). These include the regulation of cerebral artery tone, the possible role in neurogenic inflammation and the regulation of pain control, The objective of the study was to explore the L-arginine-NO pathway in M by determining plasma concentrations of NO in migraineurs during a pain-free period compared with healthy control subjects. A total of 84 consecutive patients entered the study, with M without aura (52) or with aura (32), according to IHS criteria. All of them were asked to stop any prophylactic treatment and to compile a headache diary over a period of 2 months after recruitment. One-hundred-twelve healthy subjects were used as controls. In each case venous blood was sampled after overnight fasting, and a diet without red meat or cured meats in the 48 hour preceding sampling. In M patients the sample was taken in a pain-free period. NO was assayed enzymatically as nitrites, using nitrate reductase and Griess reagent. We found significantly higher NO plasma concentrations in M patients than in controls (Mann-Whitney Rank Sum test p 0.005), and this was true also when patients with M without aura or M with aura were considered separately A correlation was found between headache frequency and NO plasma concentrations in M patients (chi square p <0.001). Furthermore NO concentrations were higher in migraineurs with a longer history of illness (Pearson's test p = 0.038). Our results are consistent with a basal activation of the L-arginine-NO pathway in M and suggest a relation between NO concentrations and severity of M.

Original languageEnglish
Pages (from-to)109-111
Number of pages3
JournalEOS Rivista di Immunologia ed Immunofarmacologia
Volume18
Issue number3-4
Publication statusPublished - 1998

Fingerprint

Migraine Disorders
Nitric Oxide
Epilepsy
Arginine
Headache
Healthy Volunteers
Neurogenic Inflammation
Nitrate Reductase
Cerebral Arteries
Nonparametric Statistics
Nitrites
Meat
Fasting
Diet
Pain
Pain-Free
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

D'Amico, D., Ferraris, A., Catania, A., Carlin, A., Leone, M., Attanasio, A., & Bussone, G. (1998). Increased basal nitric oxide plasma concentrations in migraine. EOS Rivista di Immunologia ed Immunofarmacologia, 18(3-4), 109-111.

Increased basal nitric oxide plasma concentrations in migraine. / D'Amico, D.; Ferraris, A.; Catania, A.; Carlin, A.; Leone, M.; Attanasio, A.; Bussone, G.

In: EOS Rivista di Immunologia ed Immunofarmacologia, Vol. 18, No. 3-4, 1998, p. 109-111.

Research output: Contribution to journalArticle

D'Amico, D, Ferraris, A, Catania, A, Carlin, A, Leone, M, Attanasio, A & Bussone, G 1998, 'Increased basal nitric oxide plasma concentrations in migraine', EOS Rivista di Immunologia ed Immunofarmacologia, vol. 18, no. 3-4, pp. 109-111.
D'Amico, D. ; Ferraris, A. ; Catania, A. ; Carlin, A. ; Leone, M. ; Attanasio, A. ; Bussone, G. / Increased basal nitric oxide plasma concentrations in migraine. In: EOS Rivista di Immunologia ed Immunofarmacologia. 1998 ; Vol. 18, No. 3-4. pp. 109-111.
@article{ca80a6b675b246d8a90f583c8f70f0cd,
title = "Increased basal nitric oxide plasma concentrations in migraine",
abstract = "The L-arginine-NO pathway is known to give rise to several effects that could be involved in the pathogenesis of migraine (M). These include the regulation of cerebral artery tone, the possible role in neurogenic inflammation and the regulation of pain control, The objective of the study was to explore the L-arginine-NO pathway in M by determining plasma concentrations of NO in migraineurs during a pain-free period compared with healthy control subjects. A total of 84 consecutive patients entered the study, with M without aura (52) or with aura (32), according to IHS criteria. All of them were asked to stop any prophylactic treatment and to compile a headache diary over a period of 2 months after recruitment. One-hundred-twelve healthy subjects were used as controls. In each case venous blood was sampled after overnight fasting, and a diet without red meat or cured meats in the 48 hour preceding sampling. In M patients the sample was taken in a pain-free period. NO was assayed enzymatically as nitrites, using nitrate reductase and Griess reagent. We found significantly higher NO plasma concentrations in M patients than in controls (Mann-Whitney Rank Sum test p 0.005), and this was true also when patients with M without aura or M with aura were considered separately A correlation was found between headache frequency and NO plasma concentrations in M patients (chi square p <0.001). Furthermore NO concentrations were higher in migraineurs with a longer history of illness (Pearson's test p = 0.038). Our results are consistent with a basal activation of the L-arginine-NO pathway in M and suggest a relation between NO concentrations and severity of M.",
author = "D. D'Amico and A. Ferraris and A. Catania and A. Carlin and M. Leone and A. Attanasio and G. Bussone",
year = "1998",
language = "English",
volume = "18",
pages = "109--111",
journal = "EOS Rivista di Immunologia ed Immunofarmacologia",
issn = "0392-6699",
publisher = "Sigma-Tau SpA",
number = "3-4",

}

TY - JOUR

T1 - Increased basal nitric oxide plasma concentrations in migraine

AU - D'Amico, D.

AU - Ferraris, A.

AU - Catania, A.

AU - Carlin, A.

AU - Leone, M.

AU - Attanasio, A.

AU - Bussone, G.

PY - 1998

Y1 - 1998

N2 - The L-arginine-NO pathway is known to give rise to several effects that could be involved in the pathogenesis of migraine (M). These include the regulation of cerebral artery tone, the possible role in neurogenic inflammation and the regulation of pain control, The objective of the study was to explore the L-arginine-NO pathway in M by determining plasma concentrations of NO in migraineurs during a pain-free period compared with healthy control subjects. A total of 84 consecutive patients entered the study, with M without aura (52) or with aura (32), according to IHS criteria. All of them were asked to stop any prophylactic treatment and to compile a headache diary over a period of 2 months after recruitment. One-hundred-twelve healthy subjects were used as controls. In each case venous blood was sampled after overnight fasting, and a diet without red meat or cured meats in the 48 hour preceding sampling. In M patients the sample was taken in a pain-free period. NO was assayed enzymatically as nitrites, using nitrate reductase and Griess reagent. We found significantly higher NO plasma concentrations in M patients than in controls (Mann-Whitney Rank Sum test p 0.005), and this was true also when patients with M without aura or M with aura were considered separately A correlation was found between headache frequency and NO plasma concentrations in M patients (chi square p <0.001). Furthermore NO concentrations were higher in migraineurs with a longer history of illness (Pearson's test p = 0.038). Our results are consistent with a basal activation of the L-arginine-NO pathway in M and suggest a relation between NO concentrations and severity of M.

AB - The L-arginine-NO pathway is known to give rise to several effects that could be involved in the pathogenesis of migraine (M). These include the regulation of cerebral artery tone, the possible role in neurogenic inflammation and the regulation of pain control, The objective of the study was to explore the L-arginine-NO pathway in M by determining plasma concentrations of NO in migraineurs during a pain-free period compared with healthy control subjects. A total of 84 consecutive patients entered the study, with M without aura (52) or with aura (32), according to IHS criteria. All of them were asked to stop any prophylactic treatment and to compile a headache diary over a period of 2 months after recruitment. One-hundred-twelve healthy subjects were used as controls. In each case venous blood was sampled after overnight fasting, and a diet without red meat or cured meats in the 48 hour preceding sampling. In M patients the sample was taken in a pain-free period. NO was assayed enzymatically as nitrites, using nitrate reductase and Griess reagent. We found significantly higher NO plasma concentrations in M patients than in controls (Mann-Whitney Rank Sum test p 0.005), and this was true also when patients with M without aura or M with aura were considered separately A correlation was found between headache frequency and NO plasma concentrations in M patients (chi square p <0.001). Furthermore NO concentrations were higher in migraineurs with a longer history of illness (Pearson's test p = 0.038). Our results are consistent with a basal activation of the L-arginine-NO pathway in M and suggest a relation between NO concentrations and severity of M.

UR - http://www.scopus.com/inward/record.url?scp=0032454444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032454444&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032454444

VL - 18

SP - 109

EP - 111

JO - EOS Rivista di Immunologia ed Immunofarmacologia

JF - EOS Rivista di Immunologia ed Immunofarmacologia

SN - 0392-6699

IS - 3-4

ER -