Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease

Valerio Pisani, Alessandro Stefani, Mariangela Pierantozzi, Silvia Natoli, Paolo Stanzione, Diego Franciotta, Antonio Pisani

Research output: Contribution to journalArticlepeer-review


Background: Alterations in blood-brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson's disease progression. However, few studies have addressed this issue in patients at different stages of disease.Methods: Albumin was measured in cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic Parkinson's disease and 47 age-matched control subjects. The albumin ratio (AR) was calculated to assess blood-cerebrospinal fluid and blood-brain barrier function. The group of patients with Parkinson's disease included 46 subjects with Hoehn-Yahr staging between 1 and 2 and 27, with a score ranging from 2.5 to 4.Results: Statistically significant differences in albumin ratio were found between patients with advanced disease, and both early-stage and unaffected groups. Conversely, early-phase patients did not differ from healthy subjects. Additionally, dopaminergic treatment seems to exert a possible effect on AR values.Conclusions: Our study demonstrates that possible dysfunction of the blood-cerebrospinal fluid barrier, blood-brain barrier, or both, characterize Parkinson's disease progression. The associations between clinical scores, treatments and biochemical findings suggest a progressive impairment of barrier integrity during the course of the disease.

Original languageEnglish
Article number188
JournalJournal of Neuroinflammation
Publication statusPublished - Aug 8 2012


  • Albumin ratio
  • Blood-brain barrier
  • Blood-cerebrospinal fluid barrier
  • Cerebrospinal fluid
  • Parkinson's disease

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neurology
  • Immunology
  • Neuroscience(all)


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