Increased cardiac output and lowered peripheral resistance during metoprolol treatment

John Wikstrand, Bruno Trimarco, Giuliano Buzzetti, Bruno Ricciardelli, Nicola de Luca, Massimo Volpe, Mario Condorelli

Research output: Contribution to journalArticlepeer-review


ABSTRACT Echocardiography was performed at every six months in hypertensives well controlled on metoprolol, 100 mg twice a day. After six months' treatment blood pressure was reduced from 177/110 mm Hg to 147/88 (p <0.02). LV wall thickness (septum + posterior wall) was unchanged 2.10 cm (2.14), and a significant drop in cardiac output (CO) to 5.0 1/min (6.1, p <0.02) was recorded (pretreatment values in brackets). After 24 months' treatment LV wall thickness was reduced to 1.94 cm (p <0.02), total peripheral resistance (TPR) to 17.3 mm Hg/1/min (23.4, p <0.02) and CO increased to 6.7 1/min (6.1, n.s.). After six months' treatment, there was thus a drop in BP with a significant drop in CO and unchanged TPR. After 24 months' treatment, however, CO was back to the pretreatment level and the drop in BP was entirely caused by a drop in TPR which was probably secondary to a reduction in the wall thickness of the arterial resistance vessels as judged by the relationship between the reduction in wall thickness in the LV and the reduction in TPR during the treatment. 1983 Association for the Publication of the Journal of Internal Medicine

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalActa Medica Scandinavica
Issue number672 S
Publication statusPublished - 1983


  • echocardiography
  • haemodynamics
  • hypertension
  • hypertrophy
  • metoprolol

ASJC Scopus subject areas

  • Internal Medicine


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