Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes

Gian Gastone Neri Serneri, Maria Boddi, Pietro Amedeo Modesti, Ilaria Cecioni, Mirella Coppo, Luigi Padeletti, Antonio Michelucci, Andrea Colella, Giorgio Galanti

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Physiological hypertrophy represents the adaptive changes of the heart required for supporting the increased hemodynamic load in regularly trained healthy subjects. Mechanisms responsible for the athlete's hypertrophy still remain unknown. In 15 trained competitive soccer players and in 15 healthy men not engaged in sporting activities (sedentary control subjects) of equivalent age, we investigated the relationship among cardiac growth factor formation, cardiac sympathetic activity, and left ventricular morphology and function. Cardiac formation of insulin-like growth factor (IGF)-I, endothelin (ET)-1, big ET-1, and angiotensin (Ang) II was investigated at rest by measuring artery-coronary sinus concentration gradients. Cardiac sympathetic activity was studied by [3H]norepinephrine (NE) kinetics. Cardiac IGF-I, but not ET-1, big ET-1, and Ang II, formation was higher in athletes than in control subjects (P3H]NE reuptake and clearance were not different. Echocardiographic modifications indicated a volume overload-induced hypertrophy associated with increased myocardial contractility. Multivariate stepwise analysis selected left ventricular mass index as the most predictive independent variable for cardiac IGF-I formation and velocity of circumferential fiber shortening for cardiac NE spillover. In conclusion, increased cardiac IGF-I formation and enhanced sympathetic activity selectively confined to the heart appear to be responsible for the physiological hypertrophy in athletes performing predominantly isotonic exercise.

Original languageEnglish
Pages (from-to)977-982
Number of pages6
JournalCirculation Research
Volume89
Issue number11
Publication statusPublished - Nov 23 2001

Fingerprint

Endothelin-1
Insulin-Like Growth Factor I
Athletes
Hypertrophy
Norepinephrine
Angiotensin II
Soccer
Coronary Sinus
Left Ventricular Function
Intercellular Signaling Peptides and Proteins
Healthy Volunteers
Multivariate Analysis
Arteries
Hemodynamics
Exercise

Keywords

  • Hypertrophy, left ventricular
  • Insulin-like growth factor-I
  • Norepinephrine
  • Sympathetic nervous system exercise

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Neri Serneri, G. G., Boddi, M., Modesti, P. A., Cecioni, I., Coppo, M., Padeletti, L., ... Galanti, G. (2001). Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circulation Research, 89(11), 977-982.

Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. / Neri Serneri, Gian Gastone; Boddi, Maria; Modesti, Pietro Amedeo; Cecioni, Ilaria; Coppo, Mirella; Padeletti, Luigi; Michelucci, Antonio; Colella, Andrea; Galanti, Giorgio.

In: Circulation Research, Vol. 89, No. 11, 23.11.2001, p. 977-982.

Research output: Contribution to journalArticle

Neri Serneri, GG, Boddi, M, Modesti, PA, Cecioni, I, Coppo, M, Padeletti, L, Michelucci, A, Colella, A & Galanti, G 2001, 'Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes', Circulation Research, vol. 89, no. 11, pp. 977-982.
Neri Serneri GG, Boddi M, Modesti PA, Cecioni I, Coppo M, Padeletti L et al. Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circulation Research. 2001 Nov 23;89(11):977-982.
Neri Serneri, Gian Gastone ; Boddi, Maria ; Modesti, Pietro Amedeo ; Cecioni, Ilaria ; Coppo, Mirella ; Padeletti, Luigi ; Michelucci, Antonio ; Colella, Andrea ; Galanti, Giorgio. / Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. In: Circulation Research. 2001 ; Vol. 89, No. 11. pp. 977-982.
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