TY - JOUR
T1 - Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia
AU - Baldassarre, Damiano
AU - Amato, Mauro
AU - Pustina, Linda
AU - Tremoli, Elena
AU - Sirtori, Cesare R.
AU - Calabresi, Laura
AU - Franceschini, Guido
PY - 2002
Y1 - 2002
N2 - The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study, we evaluated pre-intrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age, and plasma cholesterol. The average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than in control subjects (0.94±0.06 versus 0.69±0.04 mm, P=0.004, and 1.86±0.16 versus 1.35±0.10 mm, P=0.025, respectively). The IMT values in HyperALP subjects (Avg-IMT, 0.71±0.04 and Max-IMT, 1.38±0.14 mm) were the same as in controls. In a large cohort of hyperlipidemic subjects (n=559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (
AB - The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study, we evaluated pre-intrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age, and plasma cholesterol. The average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than in control subjects (0.94±0.06 versus 0.69±0.04 mm, P=0.004, and 1.86±0.16 versus 1.35±0.10 mm, P=0.025, respectively). The IMT values in HyperALP subjects (Avg-IMT, 0.71±0.04 and Max-IMT, 1.38±0.14 mm) were the same as in controls. In a large cohort of hyperlipidemic subjects (n=559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (
KW - High-density lipoproteins
KW - Hyperalphalipoproteinemia
KW - Hypoalphalipoproteinemia
KW - Intima-media thickness
KW - Preintrusive atherosclerosis
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U2 - 10.1161/hq0202.104848
DO - 10.1161/hq0202.104848
M3 - Article
C2 - 11834535
AN - SCOPUS:0036161911
VL - 22
SP - 317
EP - 322
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 2
ER -