Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia

Damiano Baldassarre, Mauro Amato, Linda Pustina, Elena Tremoli, Cesare R. Sirtori, Laura Calabresi, Guido Franceschini

Research output: Contribution to journalArticlepeer-review


The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study, we evaluated pre-intrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age, and plasma cholesterol. The average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than in control subjects (0.94±0.06 versus 0.69±0.04 mm, P=0.004, and 1.86±0.16 versus 1.35±0.10 mm, P=0.025, respectively). The IMT values in HyperALP subjects (Avg-IMT, 0.71±0.04 and Max-IMT, 1.38±0.14 mm) were the same as in controls. In a large cohort of hyperlipidemic subjects (n=559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number2
Publication statusPublished - 2002


  • High-density lipoproteins
  • Hyperalphalipoproteinemia
  • Hypoalphalipoproteinemia
  • Intima-media thickness
  • Preintrusive atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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