Increased carotid thickness in subjects with recently-diagnosed diabetes from rural cameroon

Nicola Napoli, Enrico Zardi, Rocky Strollo, Michele Arigliani, Andrea Daverio, Flaminia Olearo, Daniele Tosi, Giordano Dicuonzo, Filomena Scarpa, Claudio Pedone, Hervé Hilaire Tegue Simo, Giovanni Mottini, Paolo Pozzilli

Research output: Contribution to journalArticlepeer-review


Background: We have recently shown a high prevalence of diabetes and obesity in rural Cameroon, despite an improved lifestyle. Diabetes in rural Africa remains underdiagnosed and its role in increasing risk of atherosclerosis in these populations is unknown. We investigated the prevalence of carotid atherosclerosis and cardiovascular risk factors in a population of subjects with recently-diagnosed diabetes from rural Cameroon. Methodology/Principal Findings: In a case-control study, carotid intima-media thickness (IMT) was measured in 74 subjects with diabetes (diagnosed 0.9 mm was found in 4%, 45.9% and 20% of diabetic subjects at the common, bulb or internal carotid, respectively. Only 25% of patients had an HbA1c9%). The prevalence of diabetic subjects with abnormal levels of LDL-cholesterol, triglycerides, HDL-cholesterol or blood pressure was 45%, 16.6%, 15% and 65.7%, respectively. Conclusions: Carotid thickness is increased in subjects with diabetes from a rural area of Cameroon, despite the relatively recent diagnosis. These findings and the high rate of uncontrolled diabetes in this population support the increasing concern of diabetes and cardiovascular diseases in African countries and indicate the need for multifaceted health interventions in urban and rural settings.

Original languageEnglish
Article numbere41316
JournalPLoS One
Issue number8
Publication statusPublished - Aug 20 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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