Increased CD10/TdT positive cells in the bone marrow of an infant with immune thrombocytopenia

L. M A Melillo; N. Cascavilla; P. Musto; M. M. Minervini; S. Ladogana; A. La Sala; M. Carotenuto

Increased CD10/TdT positive cells in the bone marrow of an infant with immune thrombocytopenia

L. M A Melillo, N. Cascavilla, P. Musto, M. M. Minervini, S. Ladogana, A. La Sala, M. Carotenuto

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the case of an infant with immune thrombocytopenia whose bone marrow showed an increased percentage of CB10/TdT-positive lymphoid cells that resembled the onset of an acute lymphoproliferative disorder. Genotypic analysis of bone marrow, however, failed to reveal the malignant origin of these B cell precursors. After 8 months of follow-up, the child is alive and well, and shows a chronic form of ITP. Although a relation between this B cell proliferation and the onset of ITP cannot be excluded, it is important to consider this atypical pattern as a benign hematologic condition.

Original language	English
Pages (from-to)	177-179
Number of pages	3
Journal	Haematologica
Volume	79
Issue number	2
Publication status	Published - 1994

Keywords

bone marrow
CD10/TdT positive lymphocytes
immune thrombocytopenia

ASJC Scopus subject areas

Hematology

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title = "Increased CD10/TdT positive cells in the bone marrow of an infant with immune thrombocytopenia",

abstract = "We describe the case of an infant with immune thrombocytopenia whose bone marrow showed an increased percentage of CB10/TdT-positive lymphoid cells that resembled the onset of an acute lymphoproliferative disorder. Genotypic analysis of bone marrow, however, failed to reveal the malignant origin of these B cell precursors. After 8 months of follow-up, the child is alive and well, and shows a chronic form of ITP. Although a relation between this B cell proliferation and the onset of ITP cannot be excluded, it is important to consider this atypical pattern as a benign hematologic condition.",

keywords = "bone marrow, CD10/TdT positive lymphocytes, immune thrombocytopenia",

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AU - Melillo, L. M A

AU - Cascavilla, N.

AU - Musto, P.

AU - Minervini, M. M.

AU - Ladogana, S.

AU - La Sala, A.

AU - Carotenuto, M.

PY - 1994

Y1 - 1994

N2 - We describe the case of an infant with immune thrombocytopenia whose bone marrow showed an increased percentage of CB10/TdT-positive lymphoid cells that resembled the onset of an acute lymphoproliferative disorder. Genotypic analysis of bone marrow, however, failed to reveal the malignant origin of these B cell precursors. After 8 months of follow-up, the child is alive and well, and shows a chronic form of ITP. Although a relation between this B cell proliferation and the onset of ITP cannot be excluded, it is important to consider this atypical pattern as a benign hematologic condition.

AB - We describe the case of an infant with immune thrombocytopenia whose bone marrow showed an increased percentage of CB10/TdT-positive lymphoid cells that resembled the onset of an acute lymphoproliferative disorder. Genotypic analysis of bone marrow, however, failed to reveal the malignant origin of these B cell precursors. After 8 months of follow-up, the child is alive and well, and shows a chronic form of ITP. Although a relation between this B cell proliferation and the onset of ITP cannot be excluded, it is important to consider this atypical pattern as a benign hematologic condition.

KW - bone marrow

KW - CD10/TdT positive lymphocytes

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