Increased CD4+CD25+Foxp3+ T cells in peripheral blood of celiac disease patients: Correlation with dietary treatment

Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Bianco Assunta, Domenico Plantone, Giovanni Cammarota, Pietro Attilio Tonali, Anna Paola Batocchi

Research output: Contribution to journalArticle

Abstract

Regulatory CD4+ CD25+Foxp3+ T cells are involved in the regulation of immune response and inhibit protective antitumor immunity. Celiac disease (CD), a food gluten-sensitive enteropathy, is considered a T-cell-mediated autoimmune disease and is generally associated with an overall increased risk of cancer in CD patients. We observed a higher percentage of circulating CD4+CD25+Foxp3+ T cells and an increased Foxp3 expression in CD4+CD25+ T cells from untreated than from treated CD patients. In co-culture, CD4+CD25+ T cells from both treated and untreated CD patients significantly suppressed the proliferation of autologous CD4+CD25- T cells similarly to values in healthy subjects. Our study suggests that Treg proportion and Foxp3 expression in circulating CD4+CD25+ T cells could justify the increased global risk of malignancy in CD population and support the efficacy of lifelong gluten-free diet in the reduction of the cancer risk.

Original languageEnglish
Pages (from-to)430-435
Number of pages6
JournalHuman Immunology
Volume70
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Celiac disease
  • Multiple sclerosis
  • T-bet
  • Transcription factor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Frisullo, G., Nociti, V., Iorio, R., Patanella, A. K., Marti, A., Assunta, B., Plantone, D., Cammarota, G., Tonali, P. A., & Batocchi, A. P. (2009). Increased CD4+CD25+Foxp3+ T cells in peripheral blood of celiac disease patients: Correlation with dietary treatment. Human Immunology, 70(6), 430-435. https://doi.org/10.1016/j.humimm.2009.04.006