Increased cerebral blood flow after plasma-exchange in patients with familial hypercholesterolemia

A. Postiglione, A. Soricelli, N. Scarpato

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral blood flow was measured in four patients with Familial Hypercholesterolemia (three with homozygous and one with heterozygous genotype) before and long after Plasma-Exchange by isotopic technique. Plasma cholesterol dropped by 30% one day after Plasma-Exchange and was still reduced by 27% after one week. Pasma fibrinogen and globulin concentrations were decreased respectively by 36% and 26% after Plasma-Exchange, but returned to pretreatment values within few days. No change was observed in haematocrit. Mean Transit Time (M.T.T.) of both common and internal carotides improved respectively from 39.2±11 and 34.9±10 seconds (M±S.E.) to 33.8±8 (p

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalClinical Hemorheology
Volume2
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Physiology
  • Hematology

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