Increased chromosomal breakage in epileptic children after long-term treatment

P. Curatolo; V. Brinchi; R. Cusmai; P. Vignetti; P. Benedetti

doi:10.1007/BF00439256

Increased chromosomal breakage in epileptic children after long-term treatment

P. Curatolo, V. Brinchi, R. Cusmai, P. Vignetti, P. Benedetti

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.

Original language	English
Pages (from-to)	439-442
Number of pages	4
Journal	European Journal of Pediatrics
Volume	145
Issue number	5
DOIs	https://doi.org/10.1007/BF00439256
Publication status	Published - Oct 1986

Keywords

Antiepileptic drugs
Chromosomal aberrations
Long-term therapy
Mutagenic effects

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1007/BF00439256

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title = "Increased chromosomal breakage in epileptic children after long-term treatment",

abstract = "To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.",

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AU - Brinchi, V.

AU - Cusmai, R.

AU - Vignetti, P.

AU - Benedetti, P.

PY - 1986/10

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N2 - To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.

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