Abstract
To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.
| Original language | English |
|---|---|
| Pages (from-to) | 439-442 |
| Number of pages | 4 |
| Journal | European Journal of Pediatrics |
| Volume | 145 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1986 |
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Keywords
- Antiepileptic drugs
- Chromosomal aberrations
- Long-term therapy
- Mutagenic effects
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Increased chromosomal breakage in epileptic children after long-term treatment. / Curatolo, P.; Brinchi, V.; Cusmai, R.; Vignetti, P.; Benedetti, P.
In: European Journal of Pediatrics, Vol. 145, No. 5, 10.1986, p. 439-442.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased chromosomal breakage in epileptic children after long-term treatment
AU - Curatolo, P.
AU - Brinchi, V.
AU - Cusmai, R.
AU - Vignetti, P.
AU - Benedetti, P.
PY - 1986/10
Y1 - 1986/10
N2 - To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.
AB - To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.
KW - Antiepileptic drugs
KW - Chromosomal aberrations
KW - Long-term therapy
KW - Mutagenic effects
UR - http://www.scopus.com/inward/record.url?scp=0022869945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022869945&partnerID=8YFLogxK
U2 - 10.1007/BF00439256
DO - 10.1007/BF00439256
M3 - Article
VL - 145
SP - 439
EP - 442
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 5
ER -