Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement

A. Del Rosso, O. Distler, A. F. Milia, C. Emanueli, L. Ibba-Manneschi, S. Guiducci, M. L. Conforti, S. Generini, A. Pignone, S. Gay, P. Madeddu, M. Matucci-Cerinic

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In systemic sclerosis (SSc) the lack of an angiogenic response to hypoxia may be due to inappropriate synthesis of angiogenic and angiostatic factors. Tissue kallikrein (t-kallikrein), regulating the kallikrein-kinin system and acting on the microcirculation, is a potent angiogenic agent, and kallistatin is its natural inhibitor. Objective: To evaluate, in patients with SSc, t-kallikrein and kallistatin levels and their correlation with clinical features and measures of microvascular involvement. Patients and methods: Serum levels of t-kallikrein and kallistatin (ELISA) and t-kallikrein skin expression (immunohistochemistry) were studied in patients with SSc, and evaluated for subset (dSSc or ISSc), clinical and immunological features, and microvascular involvement (ulcers, telangiectasias, nailfold videocapillaroscopy). Results: Circulating levels of t-kallikrein were higher in SSc than in controls (p

Original languageEnglish
Pages (from-to)382-387
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume64
Issue number3
DOIs
Publication statusPublished - Mar 2005

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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