Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement

A. Del Rosso, O. Distler, A. F. Milia, C. Emanueli, L. Ibba-Manneschi, S. Guiducci, M. L. Conforti, S. Generini, A. Pignone, S. Gay, P. Madeddu, M. Matucci-Cerinic

Research output: Contribution to journalArticle

Abstract

Background: In systemic sclerosis (SSc) the lack of an angiogenic response to hypoxia may be due to inappropriate synthesis of angiogenic and angiostatic factors. Tissue kallikrein (t-kallikrein), regulating the kallikrein-kinin system and acting on the microcirculation, is a potent angiogenic agent, and kallistatin is its natural inhibitor. Objective: To evaluate, in patients with SSc, t-kallikrein and kallistatin levels and their correlation with clinical features and measures of microvascular involvement. Patients and methods: Serum levels of t-kallikrein and kallistatin (ELISA) and t-kallikrein skin expression (immunohistochemistry) were studied in patients with SSc, and evaluated for subset (dSSc or ISSc), clinical and immunological features, and microvascular involvement (ulcers, telangiectasias, nailfold videocapillaroscopy). Results: Circulating levels of t-kallikrein were higher in SSc than in controls (p

Original languageEnglish
Pages (from-to)382-387
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume64
Issue number3
DOIs
Publication statusPublished - Mar 2005

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Tissue Kallikreins
Systemic Scleroderma
Microscopic Angioscopy
Kallikrein-Kinin System
Microcirculation
Telangiectasis
Kinins
Kallikreins
Angiogenesis Inducing Agents
Ulcer
Skin
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Serum
kallistatin

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Del Rosso, A., Distler, O., Milia, A. F., Emanueli, C., Ibba-Manneschi, L., Guiducci, S., ... Matucci-Cerinic, M. (2005). Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement. Annals of the Rheumatic Diseases, 64(3), 382-387. https://doi.org/10.1136/ard.2004.023382

Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement. / Del Rosso, A.; Distler, O.; Milia, A. F.; Emanueli, C.; Ibba-Manneschi, L.; Guiducci, S.; Conforti, M. L.; Generini, S.; Pignone, A.; Gay, S.; Madeddu, P.; Matucci-Cerinic, M.

In: Annals of the Rheumatic Diseases, Vol. 64, No. 3, 03.2005, p. 382-387.

Research output: Contribution to journalArticle

Del Rosso, A, Distler, O, Milia, AF, Emanueli, C, Ibba-Manneschi, L, Guiducci, S, Conforti, ML, Generini, S, Pignone, A, Gay, S, Madeddu, P & Matucci-Cerinic, M 2005, 'Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement', Annals of the Rheumatic Diseases, vol. 64, no. 3, pp. 382-387. https://doi.org/10.1136/ard.2004.023382
Del Rosso, A. ; Distler, O. ; Milia, A. F. ; Emanueli, C. ; Ibba-Manneschi, L. ; Guiducci, S. ; Conforti, M. L. ; Generini, S. ; Pignone, A. ; Gay, S. ; Madeddu, P. ; Matucci-Cerinic, M. / Increased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement. In: Annals of the Rheumatic Diseases. 2005 ; Vol. 64, No. 3. pp. 382-387.
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AU - Guiducci, S.

AU - Conforti, M. L.

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AU - Madeddu, P.

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