Increased CNTF levels in adults with autism spectrum disorders

Natascia Brondino, Matteo Rocchetti, Laura Fusar-Poli, Stefano Damiani, Arianna Goggi, Giuseppe Chiodelli, Serafino Corti, Livia Visai, Pierluigi Politi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: Ciliary neurotrophic factor (CNTF) is a neurotrophin which could signal neuronal suffering and at the same time acts as a neuroprotective agent. In the present study we aimed to evaluate CNTF serum levels in autism spectrum disorders (ASDs). In fact, considering the role of CNTF as a neuronal damage signal and the role of neuroinflammation, excito-inhibitory imbalance and excitotoxicity in the pathogenesis of ASDs, a possible alteration of CNTF in ASDs could be hypothesised.

METHODS: We recruited 23 individuals with ASDs and intellectual disability (ID), 20 ID subjects and 26 typical adults. A complete medical and psychopathological characterisation of the participants was performed. CNTF serum levels were measured with ELISA.

RESULTS: CNTF serum levels were significantly higher in the ASD + ID group compared to ID (p < .001) or typically developed subjects (p < .001).

CONCLUSIONS: CNTF may be considered as a potential biomarker candidate for ASDs in the context of severe ID. Our results support the hypothesis of neurotrophic imbalance in ASDs.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalWorld Journal of Biological Psychiatry
DOIs
Publication statusPublished - 2018

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