Increased coronary blood flow and cardiac contractile efficiency with intraaortic balloon counterpulsation in a porcine model of myocardial ischemia-reperfusion injury

Sandro Gelsomino, Fabiana Lucà, Attilio Renzulli, Antonino S. Rubino, Salvatore Mario Romano, Frederik H. Van Der Veen, Rocco Carella, Joseph G. Maessen, Gian Franco Gensini, Roberto Lorusso

Research output: Contribution to journalArticle

Abstract

The evaluation of the impact of intraaortic balloon pump (IABP) on postischemic coronary perfusion and myocardial contractile impairment has been so far limited to early reperfusion phase. Therefore, we analyzed the 24-hour effects of IABP on coronary blood flow (CBF) and left ventricular performance in an animal model of acute myocardial ischemia-reperfusion injury. Healthy swine (n = 20) underwent 120-minute ligation of the left anterior descending coronary artery followed by 24 hours of reperfusion. We randomly assigned the animals to have IABP placed in the descending aorta 5 minutes after reperfusion onset (n = 10) or to undergo no implantation (n = 10). We measured CBF, coronary resistance, cardiac cycle efficiency (CCE), and maximal pressure/time ratio before ischemia was induced and at 30 minutes and 1, 6, 12, and 24 hours after reperfusion began. During diastole, CBF was significantly increased in IABP compared with baseline and controls at all time points (all p <0.001). This was also true during systole in IABP only for the first hour after reperfusion began. Additionally, both CCE and pressure/time ratio were significantly increased in IABP compared with baseline at 30 minutes and 1 hour after reperfusion began (p <0.001). IABP was associated with enhanced CBF and cardiac efficiency in a model of acute ischemic-reperfusion injury.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalASAIO Journal
Volume57
Issue number5
DOIs
Publication statusPublished - Sep 2011

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Counterpulsation
Myocardial Reperfusion Injury
Balloons
Reperfusion Injury
Reperfusion
Myocardial Ischemia
Blood
Swine
Pumps
Animals
Pressure
Diastole
Systole
Thoracic Aorta
Ligation
Coronary Vessels
Ischemia
Animal Models
Perfusion

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

Cite this

Increased coronary blood flow and cardiac contractile efficiency with intraaortic balloon counterpulsation in a porcine model of myocardial ischemia-reperfusion injury. / Gelsomino, Sandro; Lucà, Fabiana; Renzulli, Attilio; Rubino, Antonino S.; Romano, Salvatore Mario; Van Der Veen, Frederik H.; Carella, Rocco; Maessen, Joseph G.; Gensini, Gian Franco; Lorusso, Roberto.

In: ASAIO Journal, Vol. 57, No. 5, 09.2011, p. 375-381.

Research output: Contribution to journalArticle

Gelsomino, S, Lucà, F, Renzulli, A, Rubino, AS, Romano, SM, Van Der Veen, FH, Carella, R, Maessen, JG, Gensini, GF & Lorusso, R 2011, 'Increased coronary blood flow and cardiac contractile efficiency with intraaortic balloon counterpulsation in a porcine model of myocardial ischemia-reperfusion injury', ASAIO Journal, vol. 57, no. 5, pp. 375-381. https://doi.org/10.1097/MAT.0b013e31822c1539
Gelsomino, Sandro ; Lucà, Fabiana ; Renzulli, Attilio ; Rubino, Antonino S. ; Romano, Salvatore Mario ; Van Der Veen, Frederik H. ; Carella, Rocco ; Maessen, Joseph G. ; Gensini, Gian Franco ; Lorusso, Roberto. / Increased coronary blood flow and cardiac contractile efficiency with intraaortic balloon counterpulsation in a porcine model of myocardial ischemia-reperfusion injury. In: ASAIO Journal. 2011 ; Vol. 57, No. 5. pp. 375-381.
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