Increased density of dopamine D5 receptor in peripheral blood lymphocytes of migraineurs: A marker for migraine?

Piero Barbanti, Elena Bronzetti, Alberto Ricci, Rosanna Cerbo, Giovanni Fabbrini, Maria Gabriella Buzzi, Francesco Amenta, Gian Luigi Lenzi

Research output: Contribution to journalArticle

Abstract

The expression of dopamine D5 receptor was investigated in peripheral blood lymphocytes of 11 migraine patients and of ten healthy control subjects using a radioligand binding technique with [3H]SCH 23390 as a ligand. [3H]SCH 23390 is a benzazepine derivative with potent antagonist properties at the dopamine D1-like receptors. [3H]SCH 23390 was specifically bound to peripheral blood lymphocytes of migraineurs and control subjects in a manner consistent with the labelling of a dopamine D5 receptor. In migaineurs a statistically significant higher density of lymphocyte dopamine D5 receptor compared with controls was noticeable, whereas the affinity of the radioligand was unchanged. The increased density of dopamine D5 receptor in peripheral blood lymphocytes may reflect the dopaminergic hypersensitivity displayed by migraineurs and may represent a relatively simple and reliable peripheral marker of altered dopaminergic function.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalNeuroscience Letters
Volume207
Issue number2
DOIs
Publication statusPublished - Mar 29 1996

Keywords

  • Dopamine D receptor
  • Lymphocyte
  • Migraine
  • Radioligand binding

ASJC Scopus subject areas

  • Neuroscience(all)

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