Increased erythrocyte adenosine deaminase activity without haemolytic anaemia

G. Novelli, V. Stocchi, A. Giannotti, M. Magnani, B. Dallapiccola

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 4-fold increase of red blood cell adenosine deaminase (ADA) activity was found in a patient without haemolytic anaemia, but with mild anisopoikilocytosis. High-performance liquid chromatography showed a 40% reduction of adenosine-5'-triphosphate (ATP) while all the other nucleotides were in normal ranges. The patient's parents (first cousins) and a brother displayed the same enzyme activities as the controls. This observation suggests that mild increases of ADA activity is neither a marker for congenital hypoplastic anaemia as previously reported nor associated with haemolytic anaemia.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalHuman Heredity
Volume36
Issue number1
DOIs
Publication statusPublished - 1986

Fingerprint

Adenosine Deaminase
Hemolytic Anemia
Congenital Hypoplastic Anemia
Erythrocytes
Siblings
Reference Values
Nucleotides
Adenosine Triphosphate
Parents
High Pressure Liquid Chromatography
Enzymes

Keywords

  • Adenosine deaminase
  • Adenosine-5'-triphosphate
  • Haemolytic anaemia

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Increased erythrocyte adenosine deaminase activity without haemolytic anaemia. / Novelli, G.; Stocchi, V.; Giannotti, A.; Magnani, M.; Dallapiccola, B.

In: Human Heredity, Vol. 36, No. 1, 1986, p. 37-40.

Research output: Contribution to journalArticle

Novelli, G. ; Stocchi, V. ; Giannotti, A. ; Magnani, M. ; Dallapiccola, B. / Increased erythrocyte adenosine deaminase activity without haemolytic anaemia. In: Human Heredity. 1986 ; Vol. 36, No. 1. pp. 37-40.
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