Increased expression of myeloid antigen markers in adult acute lymphoblastic leukaemia patients: Diagnostic and prognostic implications

F. Lauria, D. Raspadori, G. Martinelli, D. Rondelli, M. A. Ventura, P. Farabegoli, P. Tosi, N. Testoni, G. Visani, A. Zaccaria, B. Gamberi, A. Cenacchi, S. Tura

Research output: Contribution to journalArticle

Abstract

By applying direct immunofluorescence with a dual-staining technique we were able to demonstrate that 20/37 (54%) patients with acute lymphoblastic leukaemia (ALL) expressed both lymphoid and myeloid antigens on the same leukaemic cells. CD13 and CD33 myeloid antigens were detected in 18/20 and in 15/20 cases respectively, and both in 13. Molecular studies confirmed that the four patients with T-cell phenotype had molecular rearrangement of T-cell receptor (TcR) β chain, and 26 ALL patients with 'B-cell' phenotype showed JH rearrangement. Two ALL patients without (ALL/My-) and three with myeloid antigens (ALL/My+) also demonstrated bcr/abl rearrangement. Both groups of patients had similar presenting features such as age, sex, Hb level, white blood cells, platelet counts and cytogenetic features. Complete response was achieved in 16/17 (94%) ALL/My- patients and in 15/18 (83%) ALL/My+ patients (two deaths occurred during induction) with a mean duration of 17 and 16 months respectively and with similar survival and event-free survival curves. Myeloid antigen expression in adult ALL patients may occur more frequently than previously reported. The presence of myeloid antigen does not identify, in our series, a higher-risk subgroup of patients, although lack of any statistical evidence of prognostic significance needs to be confirmed in a larger case study.

Original languageEnglish
Pages (from-to)286-292
Number of pages7
JournalBritish Journal of Haematology
Volume87
Issue number2
Publication statusPublished - 1994

Keywords

  • Acute lymphoblastic leukaemia
  • Immunofluorescence
  • Myeloid antigen markers

ASJC Scopus subject areas

  • Hematology

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