Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury

O. Kutlu; A. E. Ross; E. M. Schaeffer; C. Gratzke; C. G. Stief; T. D. Strong; A. L. Burnett; P. Hedlund; T. J. Bivalacqua

doi:10.1038/ijir.2011.50

Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury

O. Kutlu, A. E. Ross, E. M. Schaeffer, C. Gratzke, C. G. Stief, T. D. Strong, A. L. Burnett, P. Hedlund, T. J. Bivalacqua

IRCCS Ospedale San Raffaele

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Abstract

In an effort to identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we evaluated changes in the expression of nestin, an intermediate filament protein and neural stem cell marker following cavernous nerve crush injury (CNI). We utilized two groups of Sprague Dawley rats: (i) sham and (ii) bilateral CNI. Erectile responses to cavernous nerve stimulation (CNS) were determined at 48 h in a subset of rats. The MPG was isolated and removed at 48 h after CNI, and nestin immunolocalization, protein levels and RNA expression were evaluated. At 48 h, erectile responses to CNS in CNI rats were substantially reduced (P

Original language	English
Pages (from-to)	84-90
Number of pages	7
Journal	International Journal of Impotence Research
Volume	24
Issue number	2
DOIs	https://doi.org/10.1038/ijir.2011.50
Publication status	Published - Mar 2012

Keywords

erectile dysfunction
prostate cancer
radical prostatectomy
stem cell

ASJC Scopus subject areas

Urology

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10.1038/ijir.2011.50

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abstract = "In an effort to identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we evaluated changes in the expression of nestin, an intermediate filament protein and neural stem cell marker following cavernous nerve crush injury (CNI). We utilized two groups of Sprague Dawley rats: (i) sham and (ii) bilateral CNI. Erectile responses to cavernous nerve stimulation (CNS) were determined at 48 h in a subset of rats. The MPG was isolated and removed at 48 h after CNI, and nestin immunolocalization, protein levels and RNA expression were evaluated. At 48 h, erectile responses to CNS in CNI rats were substantially reduced (P",

keywords = "erectile dysfunction, prostate cancer, radical prostatectomy, stem cell",

author = "O. Kutlu and Ross, {A. E.} and Schaeffer, {E. M.} and C. Gratzke and Stief, {C. G.} and Strong, {T. D.} and Burnett, {A. L.} and P. Hedlund and Bivalacqua, {T. J.}",

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AU - Ross, A. E.

AU - Schaeffer, E. M.

AU - Gratzke, C.

AU - Stief, C. G.

AU - Strong, T. D.

AU - Burnett, A. L.

AU - Hedlund, P.

AU - Bivalacqua, T. J.

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Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury

Abstract

Keywords

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