Abstract
In an effort to identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we evaluated changes in the expression of nestin, an intermediate filament protein and neural stem cell marker following cavernous nerve crush injury (CNI). We utilized two groups of Sprague Dawley rats: (i) sham and (ii) bilateral CNI. Erectile responses to cavernous nerve stimulation (CNS) were determined at 48 h in a subset of rats. The MPG was isolated and removed at 48 h after CNI, and nestin immunolocalization, protein levels and RNA expression were evaluated. At 48 h, erectile responses to CNS in CNI rats were substantially reduced (P
| Original language | English |
|---|---|
| Pages (from-to) | 84-90 |
| Number of pages | 7 |
| Journal | International Journal of Impotence Research |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2012 |
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Keywords
- erectile dysfunction
- prostate cancer
- radical prostatectomy
- stem cell
ASJC Scopus subject areas
- Urology
Cite this
Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury. / Kutlu, O.; Ross, A. E.; Schaeffer, E. M.; Gratzke, C.; Stief, C. G.; Strong, T. D.; Burnett, A. L.; Hedlund, P.; Bivalacqua, T. J.
In: International Journal of Impotence Research, Vol. 24, No. 2, 03.2012, p. 84-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury
AU - Kutlu, O.
AU - Ross, A. E.
AU - Schaeffer, E. M.
AU - Gratzke, C.
AU - Stief, C. G.
AU - Strong, T. D.
AU - Burnett, A. L.
AU - Hedlund, P.
AU - Bivalacqua, T. J.
PY - 2012/3
Y1 - 2012/3
N2 - In an effort to identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we evaluated changes in the expression of nestin, an intermediate filament protein and neural stem cell marker following cavernous nerve crush injury (CNI). We utilized two groups of Sprague Dawley rats: (i) sham and (ii) bilateral CNI. Erectile responses to cavernous nerve stimulation (CNS) were determined at 48 h in a subset of rats. The MPG was isolated and removed at 48 h after CNI, and nestin immunolocalization, protein levels and RNA expression were evaluated. At 48 h, erectile responses to CNS in CNI rats were substantially reduced (P
AB - In an effort to identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we evaluated changes in the expression of nestin, an intermediate filament protein and neural stem cell marker following cavernous nerve crush injury (CNI). We utilized two groups of Sprague Dawley rats: (i) sham and (ii) bilateral CNI. Erectile responses to cavernous nerve stimulation (CNS) were determined at 48 h in a subset of rats. The MPG was isolated and removed at 48 h after CNI, and nestin immunolocalization, protein levels and RNA expression were evaluated. At 48 h, erectile responses to CNS in CNI rats were substantially reduced (P
KW - erectile dysfunction
KW - prostate cancer
KW - radical prostatectomy
KW - stem cell
UR - http://www.scopus.com/inward/record.url?scp=84858704689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858704689&partnerID=8YFLogxK
U2 - 10.1038/ijir.2011.50
DO - 10.1038/ijir.2011.50
M3 - Article
C2 - 21993267
AN - SCOPUS:84858704689
VL - 24
SP - 84
EP - 90
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research
SN - 0955-9930
IS - 2
ER -