Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury

O. Kutlu, A. E. Ross, E. M. Schaeffer, C. Gratzke, C. G. Stief, T. D. Strong, A. L. Burnett, P. Hedlund, T. J. Bivalacqua

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Abstract

In an effort to identify neuronal repair mechanisms of the major pelvic ganglion (MPG), we evaluated changes in the expression of nestin, an intermediate filament protein and neural stem cell marker following cavernous nerve crush injury (CNI). We utilized two groups of Sprague Dawley rats: (i) sham and (ii) bilateral CNI. Erectile responses to cavernous nerve stimulation (CNS) were determined at 48 h in a subset of rats. The MPG was isolated and removed at 48 h after CNI, and nestin immunolocalization, protein levels and RNA expression were evaluated. At 48 h, erectile responses to CNS in CNI rats were substantially reduced (P

Original languageEnglish
Pages (from-to)84-90
Number of pages7
JournalInternational Journal of Impotence Research
Volume24
Issue number2
DOIs
Publication statusPublished - Mar 2012

Keywords

  • erectile dysfunction
  • prostate cancer
  • radical prostatectomy
  • stem cell

ASJC Scopus subject areas

  • Urology

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    Kutlu, O., Ross, A. E., Schaeffer, E. M., Gratzke, C., Stief, C. G., Strong, T. D., Burnett, A. L., Hedlund, P., & Bivalacqua, T. J. (2012). Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury. International Journal of Impotence Research, 24(2), 84-90. https://doi.org/10.1038/ijir.2011.50