Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia

Antonino Mazzone, Iolanda Mazzucchelli, Monia Vezzoli, Elena Ottini, Carla Auguadro, Alessandra Serio, Colomba Falcone

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVES: The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND: Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress. METHODS: The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia. RESULTS: Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p <0.005), monocytes (p <0.001) and granulocytes (p <0.001). CONCLUSIONS: These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. (C) 2000 by the American College of Cardiology.

Original languageEnglish
Pages (from-to)746-750
Number of pages5
JournalJournal of the American College of Cardiology
Volume36
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

GABA-A Receptors
Myocardial Ischemia
Leukocytes
Exercise
Exercise Test
Pain
Flow Cytometry
Ischemia
Pain Perception
Opioid Peptides
Granulocytes
Coronary Artery Disease
Monocytes
Cohort Studies
Lymphocytes
Inflammation

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia. / Mazzone, Antonino; Mazzucchelli, Iolanda; Vezzoli, Monia; Ottini, Elena; Auguadro, Carla; Serio, Alessandra; Falcone, Colomba.

In: Journal of the American College of Cardiology, Vol. 36, No. 3, 2000, p. 746-750.

Research output: Contribution to journalArticle

Mazzone, Antonino ; Mazzucchelli, Iolanda ; Vezzoli, Monia ; Ottini, Elena ; Auguadro, Carla ; Serio, Alessandra ; Falcone, Colomba. / Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia. In: Journal of the American College of Cardiology. 2000 ; Vol. 36, No. 3. pp. 746-750.
@article{d735f348bc7c4249963ffafe278006fb,
title = "Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia",
abstract = "OBJECTIVES: The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND: Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress. METHODS: The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia. RESULTS: Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p <0.005), monocytes (p <0.001) and granulocytes (p <0.001). CONCLUSIONS: These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. (C) 2000 by the American College of Cardiology.",
author = "Antonino Mazzone and Iolanda Mazzucchelli and Monia Vezzoli and Elena Ottini and Carla Auguadro and Alessandra Serio and Colomba Falcone",
year = "2000",
doi = "10.1016/S0735-1097(00)00778-6",
language = "English",
volume = "36",
pages = "746--750",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia

AU - Mazzone, Antonino

AU - Mazzucchelli, Iolanda

AU - Vezzoli, Monia

AU - Ottini, Elena

AU - Auguadro, Carla

AU - Serio, Alessandra

AU - Falcone, Colomba

PY - 2000

Y1 - 2000

N2 - OBJECTIVES: The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND: Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress. METHODS: The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia. RESULTS: Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p <0.005), monocytes (p <0.001) and granulocytes (p <0.001). CONCLUSIONS: These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. (C) 2000 by the American College of Cardiology.

AB - OBJECTIVES: The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND: Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress. METHODS: The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia. RESULTS: Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p <0.005), monocytes (p <0.001) and granulocytes (p <0.001). CONCLUSIONS: These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. (C) 2000 by the American College of Cardiology.

UR - http://www.scopus.com/inward/record.url?scp=0033861185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033861185&partnerID=8YFLogxK

U2 - 10.1016/S0735-1097(00)00778-6

DO - 10.1016/S0735-1097(00)00778-6

M3 - Article

C2 - 10987594

AN - SCOPUS:0033861185

VL - 36

SP - 746

EP - 750

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 3

ER -