Abstract
OBJECTIVES: The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND: Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress. METHODS: The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia. RESULTS: Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p <0.005), monocytes (p <0.001) and granulocytes (p <0.001). CONCLUSIONS: These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. (C) 2000 by the American College of Cardiology.
| Original language | English |
|---|---|
| Pages (from-to) | 746-750 |
| Number of pages | 5 |
| Journal | Journal of the American College of Cardiology |
| Volume | 36 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2000 |
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Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia. / Mazzone, Antonino; Mazzucchelli, Iolanda; Vezzoli, Monia; Ottini, Elena; Auguadro, Carla; Serio, Alessandra; Falcone, Colomba.
In: Journal of the American College of Cardiology, Vol. 36, No. 3, 2000, p. 746-750.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia
AU - Mazzone, Antonino
AU - Mazzucchelli, Iolanda
AU - Vezzoli, Monia
AU - Ottini, Elena
AU - Auguadro, Carla
AU - Serio, Alessandra
AU - Falcone, Colomba
PY - 2000
Y1 - 2000
N2 - OBJECTIVES: The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND: Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress. METHODS: The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia. RESULTS: Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p <0.005), monocytes (p <0.001) and granulocytes (p <0.001). CONCLUSIONS: These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. (C) 2000 by the American College of Cardiology.
AB - OBJECTIVES: The purpose of this study was to evaluate benzodiazepine receptor expression on leukocytes from patients with symptomatic or silent myocardial ischemia. BACKGROUND: Silent myocardial ischemia is frequently observed in patients with coronary artery disease. Pain can be effectively controlled by various endogenous mechanisms. Benzodiazepines and their receptors play key roles in pain, in interactions with peptide opioids, in inflammation and in the response to stress. METHODS: The study group consisted of 57 patients with reproducible exercise-induced myocardial ischemia. The presence of a constant behavior in the anginal pain perception during both exercise-induced ischemia and daily life was the most important inclusion criterion. Venous blood samples were taken from all patients to evaluate the expression of peripheral benzodiazepine receptors by flow cytometry. The study cohort was classified into two groups: 24 patients who had anginal pain both at home and during the exercise stress test and 33 patients who were asymptomatic during both daily life and exercise-induced ischemia. RESULTS: Flow cytometry analysis showed increased expression of peripheral benzodiazepine receptors on all types of leukocytes in the asymptomatic patients. The difference was statistically significant for lymphocytes (p <0.005), monocytes (p <0.001) and granulocytes (p <0.001). CONCLUSIONS: These data show that expression of peripheral benzodiazepine receptors was higher in patients with silent myocardial ischemia than in symptomatic patients. (C) 2000 by the American College of Cardiology.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033861185&partnerID=8YFLogxK
U2 - 10.1016/S0735-1097(00)00778-6
DO - 10.1016/S0735-1097(00)00778-6
M3 - Article
C2 - 10987594
AN - SCOPUS:0033861185
VL - 36
SP - 746
EP - 750
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 3
ER -