Increased familial risk of cluster headache

M. Leone, M. B. Russell, A. Rigamonti, A. Attanasio, L. Grazzi, D. D'Amico, S. Usai, G. Bussone

Research output: Contribution to journalArticle


The authors studied the occurrence of cluster headache in the families of 220 Italian patients with cluster headache. A positive family history was found in 20% (44/220) of the families. Compared with the general population, first-degree relatives had a 39-fold significantly increased risk of cluster headache. Second-degree relatives had an eightfold significantly increased risk. The increased familial risk strongly supports the hypothesis that cluster headache has a genetic component in some families.

Original languageEnglish
Pages (from-to)1233-1236
Number of pages4
Issue number9
Publication statusPublished - May 8 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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    Leone, M., Russell, M. B., Rigamonti, A., Attanasio, A., Grazzi, L., D'Amico, D., Usai, S., & Bussone, G. (2001). Increased familial risk of cluster headache. Neurology, 56(9), 1233-1236.