Abstract
A case-control comparison within the framework of the prospective, multidisciplinary PLAT Study was performed to assess whether altered baseline fibrinolytic variables were associated with an elevated risk of ischemic thrombotic events in patients with documented coronary, cerebral, and/or peripheral atherosclerotic disease. Fibrinogen, D-dimer, tissue plasminogen activator (t-PA) antigen, and fibrinolytic activity before and after venous stasis (Δ=difference between the two values), t-PA inhibitor, and lipid levels in 60 atherosclerotic patients with a thrombotic event during the first year of follow-up were compared with those in 94 atherosclerotic patients without such events, who were matched for age, sex, and diagnosis at enrollment. Events were associated with a higher release of Δ t-PA antigen (P=.047), higher D-dimer (P=.024), and higher t-PA inhibitor (P=.001) levels. A Fibrinolytic activity was correlated inversely with t-PA inhibitor (P
| Original language | English |
|---|---|
| Pages (from-to) | 1412-1417 |
| Number of pages | 6 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 13 |
| Issue number | 10 |
| Publication status | Published - 1993 |
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Keywords
- Atherothrombosis
- D-dimer
- Fibrinolytic variables
- Ischemic events
- Plasminogen activator inhibitor
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Increased fibrin turnover and high PAI-1 activity as predictors of ischemic events in atherosclerotic patients. A case-control study. / Cortellaro, M.; Cofrancesco, E.; Boschetti, C.; Mussoni, L.; Donati, M. B.; Cardillo, M.; Catalano, M.; Gabrielli, L.; Lombardi, B.; Specchia, G.; Tavazzi, L.; Tremoli, E.; Pozzoli, E.; Turri, M.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 13, No. 10, 1993, p. 1412-1417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased fibrin turnover and high PAI-1 activity as predictors of ischemic events in atherosclerotic patients. A case-control study
AU - Cortellaro, M.
AU - Cofrancesco, E.
AU - Boschetti, C.
AU - Mussoni, L.
AU - Donati, M. B.
AU - Cardillo, M.
AU - Catalano, M.
AU - Gabrielli, L.
AU - Lombardi, B.
AU - Specchia, G.
AU - Tavazzi, L.
AU - Tremoli, E.
AU - Pozzoli, E.
AU - Turri, M.
PY - 1993
Y1 - 1993
N2 - A case-control comparison within the framework of the prospective, multidisciplinary PLAT Study was performed to assess whether altered baseline fibrinolytic variables were associated with an elevated risk of ischemic thrombotic events in patients with documented coronary, cerebral, and/or peripheral atherosclerotic disease. Fibrinogen, D-dimer, tissue plasminogen activator (t-PA) antigen, and fibrinolytic activity before and after venous stasis (Δ=difference between the two values), t-PA inhibitor, and lipid levels in 60 atherosclerotic patients with a thrombotic event during the first year of follow-up were compared with those in 94 atherosclerotic patients without such events, who were matched for age, sex, and diagnosis at enrollment. Events were associated with a higher release of Δ t-PA antigen (P=.047), higher D-dimer (P=.024), and higher t-PA inhibitor (P=.001) levels. A Fibrinolytic activity was correlated inversely with t-PA inhibitor (P
AB - A case-control comparison within the framework of the prospective, multidisciplinary PLAT Study was performed to assess whether altered baseline fibrinolytic variables were associated with an elevated risk of ischemic thrombotic events in patients with documented coronary, cerebral, and/or peripheral atherosclerotic disease. Fibrinogen, D-dimer, tissue plasminogen activator (t-PA) antigen, and fibrinolytic activity before and after venous stasis (Δ=difference between the two values), t-PA inhibitor, and lipid levels in 60 atherosclerotic patients with a thrombotic event during the first year of follow-up were compared with those in 94 atherosclerotic patients without such events, who were matched for age, sex, and diagnosis at enrollment. Events were associated with a higher release of Δ t-PA antigen (P=.047), higher D-dimer (P=.024), and higher t-PA inhibitor (P=.001) levels. A Fibrinolytic activity was correlated inversely with t-PA inhibitor (P
KW - Atherothrombosis
KW - D-dimer
KW - Fibrinolytic variables
KW - Ischemic events
KW - Plasminogen activator inhibitor
UR - http://www.scopus.com/inward/record.url?scp=0027367766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027367766&partnerID=8YFLogxK
M3 - Article
C2 - 8399077
AN - SCOPUS:0027367766
VL - 13
SP - 1412
EP - 1417
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 10
ER -